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Effect of biotin on alkaloid production during submerged cultivation of Claviceps sp. strain SD-58



Effect of biotin on alkaloid production during submerged cultivation of Claviceps sp. strain SD-58



Applied and Environmental Microbiology 45(5): 1694-1696



Addition of biotin to culture medium NL-406 significantly increased alkaloid yield during submerged cultivation of Claviceps sp. strain SD-58. Alkaloid yield was further enhanced by incorporating leucine in biotin-supplemented culture medium. Increased alkaloid production was associated with an increase in the lipid content of cells and in the number of chlamydospores. Biotin deficiency caused a reduction in alkaloid yield and a parallel decrease in lipid content and chlamydospore numbers.

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Accession: 017870853

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PMID: 6870245



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