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Effect of brief exercise on circulating insulin-like growth factor I



Effect of brief exercise on circulating insulin-like growth factor I



Journal of Applied Physiology 76(6): 2490-2496



An acute insulin-like growth factor I (IGF-I) response to 10 min of above-lactate threshold cycle ergometer exercise was studied in 10 subjects (age 22-35 yr). Each subject exercised on three separate mornings after ingesting one of two isocaloric isovolemic liquid meals high in either fat or glucose or an isovolemic noncaloric placebo. The high-fat meal attenuated the growth hormone (GH) response (Cappon et al., J Clin. Endocrinol. Metab. 76:1418-1422,1993). In contrast, IGF-I increased equally for all protocols (e.g., after the placebo meal IGF-I increased from 21,716 (SE) ng/ml preexercise to 25,316 ng/ml at 10 min of exercise; P lt 0.051. IGF-I peaked by the 10th min of exercise, like GH, and remained significantly elevated for only 20 min of recovery. We tested for possible GH-dependent mechanisms in which circulating IGF-I would increase 1224 h after exercise. Ten subjects (age 23-32 yr) performed 10 min of above-lactate threshold exercise at 9, 10, and 11 A.M. GH was elevated after the first exercise bout (peak GH 6.05 +- 1.45 ng/ml; P lt 0.001) but was significantly reduced for the second and third bouts (peak GH 2.52 +- 0.76 and 1.50 +- 0.40 ng/ml, respectively). No increase in IGF-I was observed by 8 A.M. on the following day. Heavy ergometer exercise led to brief and small increases in circulating IGF-I that were independent of circulating GH. The role, if any, of the GH-IGF-I axis in anabolic effects of exercise may be difficult to evaluate from circulating levels of IGF-I measured over short time intervals.

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Accession: 017870881

Download citation: RISBibTeXText

PMID: 7928875

DOI: 10.1152/jappl.1994.76.6.2490


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