EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine on hippocampal serotoninergic system, studied in freely moving rats



Effect of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine on hippocampal serotoninergic system, studied in freely moving rats



Life Sciences 46(3 ): 7-205



The effects of the anxiolytic drug buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1PP) were studied on the serotoninergic system in the hippocampus of freely moving rats. Pulse voltammetry was used in association with chronically implanted carbon fiber microelectrodes to record 5HIAA, the serotonin metabolite in the extracellular space, almost continuously. Buspirone, 2.5 mg/kg i.p. was ineffective, but the dose of 10 mg/kg lowered 5HIAA between about 45 and 150 min; the same decrease was obtained with 40 mg/kg. This effect can be explained by an agonistic action on 5HT1 A receptors. The metabolite 1PP, which displays 2 adrenoceptor blocking properties, either had no effect or raised extracellular 5HIAA, depending on the dose (1.5 or 6 mg/kg). The rapid metabolization of buspirone to 1PP can thus explain the short time course of the drug effect. Pretreatment with 1PP could only partially prevent buspirone's effect on the serotoninergic system.

(PDF same-day service: $19.90)

Accession: 017870892

Download citation: RISBibTeXText

PMID: 1689445

DOI: 10.1016/0024-3205(90)90105-z



Related references

Effect of buspirone and its metabolite 1 2 pyrimidinylpiperazine on hippocampal serotoninergic system in freely moving rats. Life Sciences 46(3): 197-206, 1990

Comparison of the anticonflict effect of buspirone and its major metabolite 1- piperazine in rats. Japanese Journal of Pharmacology 61(4): 311-317, 1993

Comparison of the anticonflict effect of buspirone and its major metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in rats. Japanese Journal of Pharmacology 61(4): 311-317, 1993

Contrasting effects of D- and L- -4- piperazine-2-carboxylic acid as anticonvulsants and as inhibitors of potassium-evoked increases in hippocampal extracellular glutamate and aspartate levels in freely moving rats. Journal of Neurochemistry 62(1): 217-222, 1994

Contrasting effects of D- and L-(E)-4-(3-phosphono-2-propenyl)piperazine-2-carboxylic acid as anticonvulsants and as inhibitors of potassium-evoked increases in hippocampal extracellular glutamate and aspartate levels in freely moving rats. Journal of Neurochemistry 62(1): 217-222, 1994

Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology 28(8): 799-803, 1989

Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats. Journal of Pharmacology and Experimental Therapeutics 303(3): 1130-1137, 2002

Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone. Pharmacology & Toxicology 84(2): 94-97, 1999

Effects of buspirone and its metabolite, 1-(2-pyrimidinyl)piperazine, on brain monoamines and their metabolites in rats. Journal of Pharmacology and Experimental Therapeutics 248(1): 50-56, 1989

Effect of stress on serotonin release as studied by transcerebral dialysis in freely moving rats. Neuroscience Letters Supplement (39): S37, 1990

Selective effects of buspirone, a new non-benzodiazepine anxiolytic drug, on the hippocampal serotoninergic system. Medicina 8(2): 200-202, 1988

Effect of a pyridinium metabolite derived from haloperidol on the activities of striatal tyrosine hydroxylase in freely moving rats. Neuroscience Letters. 214(2-3): 183-186, 1996

Effect of delta 9 tetrahydrocannabinol on hippocampal physiology in unanesthetized freely moving male rats. Society for Neuroscience Abstracts 12(1): 520, 1986

Effect of A-1 receptor agonists and antagonists on hippocampal acetylcholine release in freely moving rats. Research Communications in Molecular Pathology & Pharmacology 87(1): 97-98, 1995

Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). Biological & Pharmaceutical Bulletin 28(4): 733-735, 2005