+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effect of cardiogenic gas mixing on arterial O2 and CO2 tensions during breath holding



Effect of cardiogenic gas mixing on arterial O2 and CO2 tensions during breath holding



Journal of Applied Physiology 62(4): 1453-1459



To examine the effect of cardiogenic gas mixing on gas exchange we measured arterial tension of O2 (PaO2) and arterial tension of CO2 (PaCO2) during 3- to 5-min breath holds (BH) before and after infusing 50 ml of saline into the pericardial space (PCF) of seven anesthetized, paralyzed, mechanically ventilated dogs. During BH the ventilator was disconnected and a bias flow of 50% O2 at 4-5 l/min was delivered through the side ports of a small catheter whose tip was positioned 1 cm cephalad of the carina. Paired runs, alternately with and without PCF, were performed in triplicate in each dog. Initial PaO2 was similar for control runs [81 +/- 3 mmHg (SE)] and PCF runs (78 +/- 3 mmHg; P greater than 0.1). After 3-min BH, PaO2 in PCF runs (33 +/- 3 mmHg) was less than that in control runs (58 +/- 4 mmHg) (P less than 0.001). In contrast, the pattern of PaCO2 during BH did not differ with PCF. After 3-min BH, PaCO2 was 49 +/- 3 mmHg with PCF and 49 +/- 2 mmHg in the control runs (P greater than 0.7). In two dogs, repeated 50-ml reductions in lung volume, produced by rib cage compression, did not alter the time course of PaO2 during BH. Although cardiac output decreased slightly with PCF, hemodynamic changes due to PCF were unlikely to account for the observed fall in PaO2. Our results indicate a substantial effect of cardiogenic gas mixing on O2 uptake when tracheal gas is O2 enriched during breath holding.

(PDF emailed within 1 workday: $29.90)

Accession: 017870989

Download citation: RISBibTeXText

PMID: 3110119


Related references

Effect of breath holding time bh on gas mixing and 3 equation diffusing capacity at low inspired volumes. FASEB Journal 4(4): A944, 1990

How obesity affects alveolar gas tensions during voluntary breath holding. Federation Proceedings 45(4): 784, 1986

Hyperventilation, breath holding and alveolar oxygen tensions at the breaking point. Respiration Physiology 19(2): 201-209, 1973

The effect of breath holding on arterial oxygen saturation following exercise in man. Journal of Physiology (Cambridge) 525P: 31P-32P, 2000

Effect of cardiogenic gas mixing on alveolar arterial po 2 difference during hypoventilation. American Review of Respiratory Disease 137(4 PART 2): 270, 1988

Effect of breath holding on arterial pressure in patients with mental and emotional disorders. A.M.A. Archives of Neurology and Psychiatry 68(3): 318-320, 1952

Arterial oxygen saturation and heart rate variation during breath-holding: comparison between breath-hold divers and controls. International Journal of Sports Medicine 26(3): 177-181, 2005

Mechanism of intra pulmonary gas mixing during breath holding in man. Physiologist 15(3): 295, 1972

Gas mixing during breath holding studied by intrapulmonary gas sampling. Journal of Applied Physiology 35(1): 9-17, 1973

A comparison of the physiological responses to underwater arm cranking and breath holding between synchronized swimmers and breath holding untrained women. Journal of Human Kinetics 32: 147-156, 2013

Changes in the period of no respiratory sensation and total breath-holding time in successive breath-holding trials. Clinical Science 91(6): 755-761, 1996

Cardiogenic gas mixing cgm in lungs of closed chest dogs studied by single breath test sbt. FASEB Journal 4(3): A421, 1990

Arterial blood gas tensions during breath-hold diving in the Korean ama. Journal of Applied Physiology 75(1): 285-293, 1993

Breath holding and success in stopping smoking what does breath holding measure. International Journal of the Addictions 24(7): 633-640, 1989

The effect of breath holding on the single breath nitrogen washout. American Review of Respiratory Disease 109(6): 693-694, 1974