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Influence of switch region length on immunoglobulin class switch recombination



Influence of switch region length on immunoglobulin class switch recombination



Proceedings of the National Academy of Sciences of the United States of America 102(7): 2466-2470



The class and effector functions of antibodies are modulated through the process of Ig heavy chain class switch recombination (CSR). CSR occurs between switch (S) regions that lie upstream of the various Ig heavy chain constant region exons. Molecular analyses of S-region functions have been hampered by their large size and repetitive nature.

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Accession: 017961160

Download citation: RISBibTeXText

PMID: 15684074

DOI: 10.1073/pnas.0409847102


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