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Nitrogen narcosis and pressure reversal of anesthetic effects in node of Ranvier






American Journal of Physiology 246(1 Pt 1): C91-C95

Nitrogen narcosis and pressure reversal of anesthetic effects in node of Ranvier

To compare sodium channel block by hyperbaric nitrogen with that induced by other anesthetics and to examine the basis for pressure antagonism to anesthetic condition block, voltage clamped nodes of Ranvier were exposed to nitrogen at pressures at 1-14 atm alone and in combination with helium to a total pressure of up to 100 atm. At 7 and 14 atm nitrogen, sodium currents were reversibly depressed without accompanying changes in the current-voltage relation.

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Accession: 018029154

PMID: 6696061

DOI: 10.1148/radiology.150.3.6695089



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