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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

Annual Review of Cell and Developmental Biology 15: 551-578

ISSN/ISBN: 1081-0706

PMID: 10611972

DOI: 10.1146/annurev.cellbio.15.1.551

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS transcription factor consisting of HIF-1 alpha and HIF-1 beta subunits. HIF-1 alpha expression and HIF-1 transcriptional activity increase exponentially as cellular O2 concentration is decreased. Several dozen target genes that are transactivated by HIF-1 have been identified, including those encoding erythropoietin, glucose transporters, glycolytic enzymes, and vascular endothelial growth factor.

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