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Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference


Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference



Journal of Biological Chemistry 279(6): 5042-5046



ISSN/ISBN: 0021-9258

PMID: 14645220

DOI: 10.1074/jbc.m312477200

Epithelial Na+ transport is regulated in large part by mechanisms that control expression of the epithelial Na+ channel (ENaC) at the cell surface. Nedd4 and Nedd4-2 are candidates to control ENaC surface expression, but it is not known which of these proteins contributes to ENaC regulation in epithelia. To address this question, we used RNA interference to selectively reduce expression of Nedd4 or Nedd4-2.

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Accession: 018092614

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Relative contribuition of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference. Journal of Biological Chemistry 279(6): 5042-5046, 2004

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