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Replication fork stalling at natural impediments

Replication fork stalling at natural impediments

Microbiology and Molecular Biology Reviews: Mmbr 71(1): 13-35

ISSN/ISBN: 1092-2172

PMID: 17347517

DOI: 10.1128/mmbr.00030-06

Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way.

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Accession: 018094027

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