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Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments

Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments

Journal of Immunology 166(11): 6640-6646

ISSN/ISBN: 0022-1767

PMID: 11359818

DOI: 10.4049/jimmunol.166.11.6640

Lymphocytes need rigidity while in circulation, but must abruptly become deformable to undergo transmigration into tissue. Previously, the control of leukocyte deformability has been attributed to microfilaments or microtubules, but the present studies demonstrate the greater importance of vimentin intermediate filaments (IFs). In circulating T lymphocytes, IFs form a distinctive spherical cage that undergoes a rapid condensation into a juxtanuclear aggregate during chemokine-induced polarization. Measurements of the resistance of peripheral blood T lymphocytes to global deformation demonstrate that their rigidity is primarily dependent on intact vimentin filaments. Microtubules, in contrast, are not sufficient to maintain rigidity. Thus, vimentin IFs are a primary source of structural support in circulating human lymphocytes, and their regulated collapse is likely to be an essential element in chemokine-induced transendothelial migration.

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Accession: 018100232

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