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Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading


Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading



Physiological Reviews 84(2): 649-698



ISSN/ISBN: 0031-9333

PMID: 15044685

DOI: 10.1152/physrev.00031.2003

The extracellular matrix (ECM), and especially the connective tissue with its collagen, links tissues of the body together and plays an important role in the force transmission and tissue structure maintenance especially in tendons, ligaments, bone, and muscle. The ECM turnover is influenced by physical activity, and both collagen synthesis and degrading metalloprotease enzymes increase with mechanical loading.

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Accession: 018101148

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