EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes


Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes



Annual Review of Cell Biology 10: 181-205



ISSN/ISBN: 0743-4634

PMID: 7888176

DOI: 10.1146/annurev.cb.10.110194.001145

Lower eukaryotes such as the yeast Saccharomyces cerevisiae and the filamentous fungus Aspergillus nidulans possess a multiplicity of amino acid transporters or permeases which exhibit different properties with respect to substrate affinity, specificity, capacity and regulation. Regulation of amino acid uptake in response to physiological conditions of growth is achieved principally by a dual mechanism; control of gene expression, mediated by a complex interplay of pathway-specific and wide-domain transcription regulatory proteins, and control of transport activities, mediated by a series of protein factors, including a kinase, and possibly, by amino acids. All fungal and a number of bacterial amino acid permeases show significant sequence similarities (33-62% identity scores in binary comparisons), revealing a unique transporter family conserved across the prokaryotic-eukaryotic boundary. Prediction of the topology of this transporter family utilizing a multiple sequence alignment strongly suggests the presence of a common structural motif consisting of 12 alpha-helical putative transmembrane segments and cytoplasmically located N- and C-terminal hydrophilic regions. Interestingly, recent genetic and molecular results strongly suggest that yeast amino acid permeases are integrated into the plasma membrane through a specific intracellular translocation system. Finally, speculating on their predicted structure and on amino acid sequence similarities conserved within this family of permeases reveals regions of putative importance in amino acid transporter structure, function, post-translational regulation or biogenesis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 018102583

Download citation: RISBibTeXText

Related references

Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration. Journal of Biological Chemistry 282(42): 30629-30642, 2007

Oxidative stress: from modification of cell-cycle related events, secondary messenger function, dysregulation of small GTPases, protein kinases and phosphatases to redox-sensitive cancer models. Archives of Toxicology 82(5): 271-272, 2008

Signaling by Small GTPases at Cell-Cell Junctions: Protein Interactions Building Control and Networks. Cold Spring Harbor perspectives in biology 10(10), 2018

Chemical modification of Nafion membranes by protic ionic liquids: the key role of ionomer-cation interactions. Soft Matter 10(39): 7819-7825, 2014

Role of Plasmodium falciparum thrombospondin-related anonymous protein in host-cell interactions. Malaria Journal 7: 63, 2008

Effect of structural modification of membrane proteins on lipid-protein interactions in the human erythrocyte membranes. Bulletin of Experimental Biology and Medicine 116(5): 1364-1367, 1993

Role of zeta protein kinase C as a regulator of rho family GTPases activity and cell motility. Proceedings of the American Association for Cancer Research Annual Meeting 42: 174, 2001

Epidermal growth factor modification of radioresistance related to cell-cell interactions. International Journal of Radiation Oncology Biology Physics 20(2): 315-318, 1991

Role of lipid polymorphism in G protein-membrane interactions: Nonlamellar-prone phospholipids and peripheral protein binding to membranes. Proceedings of the National Academy of Sciences of the United States of America 94(21): 11375-11380, 1997

Impact of protein modification on the protein corona on nanoparticles and nanoparticle-cell interactions. Acs Nano 8(1): 503-513, 2014

Competitive Binding of Protein Kinase Ca to Membranes and Rho GTPases. Biochemistry (American Chemical Society) 45(48): 452-65, 2006

Kinetics of protein modification reactions stoichiometry of modification produced enzyme inactivation modification of rhodanese by 2 4 6 trinitrobenzenesulfonic acid. Biochemical Journal 230(1): 89-94, 1985

Kinetics of protein-modification reactions. Stoichiometry of modification-produced enzyme inactivation: modification of rhodanese by 2,4,6-trinitrobenzenesulphonic acid. Biochemical Journal 230(1): 89-93, 1985

Yeast two-hybrid system to detect protein-protein interactions with Rho GTPases. Methods in Enzymology 256: 228-241, 1995

The identification of protein domains that mediate functional interactions between Rab-GTPases and RabGAPs using 3D protein modeling. Advances and Applications in Bioinformatics and Chemistry: Aabc 10: 47-56, 2017