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Selection of the T cell repertoire

Selection of the T cell repertoire

Annual Review of Immunology 17: 829-874

ISSN/ISBN: 0732-0582

PMID: 10358775

DOI: 10.1146/annurev.immunol.17.1.829

Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death.

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Accession: 018109789

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