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Self-splicing RNA and an RNA enzyme in Tetrahymena


Self-splicing RNA and an RNA enzyme in Tetrahymena



Journal of Protozoology 34(4): 416-417



ISSN/ISBN: 0022-3921

PMID: 3323479

The RNA molecules transcribed from many eukaryotic genes are interrupted by intervening sequences, which are removed by a process called RNA splicing. One structurally related group of intervening sequences, the group I intervening sequences, are found in a variety of microorganisms. Some of these, including the group I intervening sequence from the ribosomal RNA precursor of Tetrahymena thermophila, have been shown to mediate their own splicing in an RNA-catalyzed reaction. Following its excision from the ribosomal RNA precursor, the Tetrahymena intervening sequence acts as an enzyme, cutting and rejoining RNA substrates.

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Accession: 018110867

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Related references

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell 47(2): 207-216, 1986

Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. Cold Spring Harbor Symposia on Quantitative Biology 52: 147-157, 1987

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