+ Translate
+ Most Popular
Investigations on the organic drift in North Swedish streams
Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research
Phloem necrosis of coffee in Surinam
Anatomy of Mystus seenghala IV Nervous system
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Tetrapleure (Tetrapleura tetraptera), an unknown African medicinal and spice plant
The origin and phylogenetic significance of the trochophoran larvae 2. evolutionary significance of the larvae of coelomate worms and mollusks
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Enterobacter amnigenus. An unusual human pathogen
Influence of Seriboost foliar application on leaf yield and leaf protein content in mulberry (Morus spp.), in relation to silkworm cocoon production
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
'Pan-sukh' disease of Rice in the Central Provinces
Geological age of the Ptilophyllum flora; a critical reassessment
Study of vitellogenesis in birds; physiological phases & role of folliculin in vitellogenesis
Evaluation of WCT coconut and Komadan coconut
Therapy for acne with saccharomyces boulardii
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Manufacture of Ricotta cheese from whey fortified with skim milk powder using different acidulants
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
Factors affecting fruitfulness in durian (Durio zibethinus Murr.). I. Flowering and pollination
Bronchial cuff pressure change caused by left-sided double-lumen endobronchial tube displacement
Some Biological Applications of Organometallic Compounds
The composition of pampas-grass (Cortaderia argentea.)

Stress proteins and immunology

Stress proteins and immunology

Annual Review of Immunology 8: 401-420

ISSN/ISBN: 0732-0582

PMID: 2188668

DOI: 10.1146/annurev.iy.08.040190.002153

We have presented evidence in this review for the following: (a) Macrophages are likely the first cell infected by HIV. Recovery of HIV from macrophages has been documented in the early stages of infection in which virus isolation in T cells is unsuccessful and detectable levels of antibodies against HIV are absent. (b) Macrophages are major reservoirs for HIV during all stages of infection. Unlike the lytic infection of T cells, HIV-infected macrophages show little or no virus-induced cytopathic effects. HIV-infected macrophages persist in tissue for extended periods of time (months) with large numbers of infectious particles contained within intracytoplasmic vacuoles. (c) Macrophages are a vector for the spread of infection to different tissues within the patient and between individuals. Several studies suggest a "Trojan horse" role for HIV-infected macrophages in the dissemination of infectious particles. The predominant cell in most bodily fluids (alveolar fluid, colostrum, semen, vaginal secretions) is the macrophage. In semen, for example, the numbers of macrophages exceed those of lymphocytes by more than 20-fold. (d) Macrophages are major regulatory cells that control the pace and intensity of disease progression in HIV infection. Macrophage secretory products are implicated in the pathogenesis of CNS disease and in control of viral latency in HIV-infected T cells. This litany of events in which macrophages participate in HIV-infection in humans parallels similar observations in such animal lentivirus infections as visna-maedi or caprine arthritis-encephalitis viruses. HIV interacts with monocytes differently than with T cells. Understanding this interaction may more clearly define both the pathogenesis of HIV disease and strategies for therapeutic intervention.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 018129870

Download citation: RISBibTeXText

Related references

The immunology of cellular stress proteins. Frontiers in Immunology 4: 153, 2013

Nonspecific stabilization of stress-susceptible proteins by stress-resistant proteins: a model for the biological role of heat shock proteins. Proceedings of the National Academy of Sciences of the United States of America 79(23): 7107-7111, 1982

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins. Journal of Biological Chemistry 258(11): 7102-7111, 1983

Social stress paradigms in male mice: Variations in behavior, stress and immunology. Physiology and Behavior 73(1-2): 165-173, 2001

Plasma radioactivity following simultaneous oral administration of intrinsic factor-bound and free radioactsis agammaglobulinemia immunology immunologic deficiency syndromes immunology iga igm intestinal mucosa immunology antibody foive vitamin B 12. Acta Haematologica 48(3): 137-144, 1972

Release of stress proteins from Mesocestoides corti is a brefeldin A-inhibitable process: evidence for active export of stress proteins. Infection and Immunity 61(6): 2596-2601, 1993

Role of immunity to mycobacterial stress proteins in rheumatoid arthritis stress proteins in inflammation london england uk may 1989. Journal of Experimental Pathology 71(2): 295-303, 1990

The retinoic acid stimulation of stress proteins and their immunochemical homology with stress proteins from other tissue sources. Teratology 33(3): 72C-73C, 1986

Perspectives of the immunology of proteins. Advances in Experimental Medicine and Biology 185: 1-25, 1985

Stress and immunology. Journal of Cellular Biochemistry Suppl (12 Part D): 307, 1988

Immunology of epidermal fibrous proteins. Journal of Investigative Dermatology 67(4): 521-525, 1976

Structure and immunology of link proteins. Federation Proceedings 41(3): ABSTRACT 3414, 1982

Proteins in rheumatology and clinical immunology. Therapeutische Umschau. Revue Therapeutique 68(11): 603-609, 2011

Immunology of myelin basic proteins. Brady, Roscoe O (Ed ) The Nervous System, Vol 1 The Basic Neurosciences Lxii+685p Illus Raven Press, Publishers: New York, N Y , U S A ISBN 0-89004-075-3: 637-646, 1975

Weaned-pig immunology and stress. Compendium on continuing education for the practicing veterinarian: 21S144-S147, 1999