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Structure, function, and formation of biological iron-sulfur clusters

Structure, function, and formation of biological iron-sulfur clusters

Annual Review of Biochemistry 74: 247-281

ISSN/ISBN: 0066-4154

PMID: 15952888

DOI: 10.1146/annurev.biochem.74.082803.133518

Iron-sulfur clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes. Owing to their remarkable structural plasticity and versatile chemical/electronic features clusters participate in electron transfer, substrate binding/activation, iron/sulfur storage, regulation of gene expression, and enzyme activity. Formation of intracellular clusters does not occur spontaneously but requires a complex biosynthetic machinery.

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Accession: 018133795

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