EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs


Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs



Cold Spring Harbor Symposia on Quantitative Biology 71: 59-66



ISSN/ISBN: 0091-7451

PMID: 17381281

DOI: 10.1101/sqb.2006.71.050

Each step in the biogenesis of microRNAs (miRNAs) depends on recognition of a correct substrate and efficient transport or processing of that RNA. Exportin5 (Exp5) and Dicer are proteins that mediate two key steps in this cascade, the nuclear export and cytoplasmic processing of microRNA precursor (pre-miRNAs).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 018136370

Download citation: RISBibTeXText

Related references

Selectivity of Exportin 5 binding to human precursor microRNAs. Rna Biology 2021: 1-8, 2021

Major regulators of micro RNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer. Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine 32(4): 769-776, 2011

Exportin t and Exportin 5: tRNA and miRNA biogenesis - and beyond. Biological Chemistry 393(7): 599-604, 2012

Dicer-Like Proteins Regulate Sexual Development via the Biogenesis of Perithecium-Specific MicroRNAs in a Plant Pathogenic Fungus Fusarium graminearum. Frontiers in Microbiology 9: 818, 2018

A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle 13(11): 1671-1676, 2014

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder. Journal of Surgical Oncology 107(2): 201-205, 2013

The Role of Exportin-5 in MicroRNA Biogenesis and Cancer. Genomics Proteomics and Bioinformatics 16(2): 120-126, 2018

Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Molecular Cell 45(2): 222-232, 2012

An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. Proceedings of the National Academy of Sciences of the United States of America 114(25): E4961-E4970, 2017

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes and Development 17(24): 3011-3016, 2003

Steroidal regulation of uterine mi RNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1. Endocrine 37(2): 265-273, 2010

Pharmacogenetics of micro RNAs and micro RNAs biogenesis machinery in pediatric acute lymphoblastic leukemia. Plos one 9(3): E91261, 2014

A genetic defect in exportin-5 traps precursor micro RNAs in the nucleus of cancer cells. Cancer Cell 18(4): 303-315, 2010

Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. Rna 11(2): 220-226, 2005

Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies. Journal of Molecular Biology 374(3): 764-776, 2007