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Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs

Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs

Cold Spring Harbor Symposia on Quantitative Biology 71: 59-66

ISSN/ISBN: 0091-7451

PMID: 17381281

DOI: 10.1101/sqb.2006.71.050

Each step in the biogenesis of microRNAs (miRNAs) depends on recognition of a correct substrate and efficient transport or processing of that RNA. Exportin5 (Exp5) and Dicer are proteins that mediate two key steps in this cascade, the nuclear export and cytoplasmic processing of microRNA precursor (pre-miRNAs).

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Accession: 018136370

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