Suppression of Cholesterol 7a-Hydroxylase Transcription and Bile Acid Synthesis by an a1-Antitrypsin Peptide via Interaction with a1-Fetoprotein Transcription Factor

Suppression of cholesterol 7alpha-hydroxylase transcription and bile acid synthesis by an alpha1-antitrypsin peptide via interaction with alpha1-fetoprotein transcription factor. Journal of Biological Chemistry 277(45): 42973-42980, 2002

A1-fetoprotein transcription factor is required for the expression of sterol 12a-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. The Journal of Biological Chemistry 275(23): 793-9, 2000

Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. Journal of Biological Chemistry 275(23): 17793-17799, 2000

On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha. Biochimica et Biophysica Acta 1583(1): 63-73, 2002

On the mechanism of bile acid inhibition of rat sterol 12 -hydroxylase gene transcription by nuclear receptors, -fetoprotein transcription factor and hepatocyte nuclear receptor 4. FASEB Journal 16(4): A562-A563, 2002

Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription. Nucleic Acids Research 28(18): 3587-3593, 2000

The negative effects of bile acids and tumor necrosis factor-a on the transcription of cholesterol 7a-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. The Journal of Biological Chemistry 276(33): 708-16, 2001

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. Journal of Biological Chemistry 276(33): 30708-30716, 2001

Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcription. Hepatology 21(2): 501-510, 1995

4.P.176 Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by down-regulation of cholesterol 7-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Atherosclerosis 134(1-2): 333, 1997

Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Arteriosclerosis Thrombosis and Vascular Biology 17(11): 3064-3070, 1997

The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis. Journal of Biological Chemistry 279(16): 16813-16821, 2004

Bile acid induced signal transductive pathways involved in regulation of cholesterol 7a-hydroxylase transcription. Gastroenterology 118(4 Suppl 2 Part 1): A2, 2000

The Role of a 1-Fetoprotein Transcription Factor/LRH-1 in Bile Acid Biosynthesis. A Known Nuclear Receptor Activator that can Act as a Suppressor of Bile Acid Biosynthesis. The Journal of Biological Chemistry 279(16): 813-21, 2004

Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity. Hepatology 12(5): 1209-1215, 1990