EurekaMag
+ Translate
+ Most Popular
Sympathetic and visceral nerve blocks
What should be done after bee or wasp stings?
Anti-drool cheiloplasty: clinical results in six dogs
The biology of human starvation: some new insights
Vitamin B12 deficiency as a worldwide problem
Effect of daily gelatin ingestion on human scalp hair
On the nature and role of vivotoxins in plant disease
History of the discovery of vitamins by N. I. Lunin
Preliminary tests with residual sprays against poultry lice
MDU.1, a new mutant chilli variety
A study on compatibility of some insecticides with a fungicide on small cardamom (Elettaria cardamomum Maton.)
The cranial nerves of Mystus seenghala (Sykes)
The effects of prefrontal lobotomy on aggressive behavior in dogs
Human monkeypox: disease pattern, incidence and attack rates in a rural area of northern Zaire
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Therapy for acne with saccharomyces boulardii
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
The composition of pampas-grass (Cortaderia argentea.)
Productivity of Pekin x Khaki Campbell ducks
A rapid survey of katydids (Insecta: Orthoptera: Tettigoniidae) of the Foret Classee du Pic de Fon, Guinea
Cranial nerves of Labeo rohita (Ham.)
Evaluating fundamentals of care: The development of a unit-level quality measurement and improvement programme
Life-cycle of the free-living nematode Pontonema vulgare in the White Sea
Grey leaf blight - a new disease of cocoa
Effect of foliar spray of urea and zinc sulphate on yield and fruit quality of Kinnow - 'a mandarin hybrid'

T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule


T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule



Journal of Immunology 162(3): 1415-1422



ISSN/ISBN: 0022-1767

PMID: 9973397

In this study we characterized the human T cell-reactive sites of the major cow dander allergen, Bos d 2, a member of the lipocalin protein family. We showed that Bos d 2 contains only a limited number of epitopes. This is in contrast to many other allergens, which usually contain multiple T cell epitopes throughout the molecule. The epitopes of Bos d 2 were primarily concentrated in the conserved regions of the molecule. One of the epitopes was recognized by all the cow-asthmatic individuals regardless of their HLA phenotype. Computer-predicted T cell epitopes on Bos d 2, other lipocalin allergens, and human endogenous lipocalins were situated in similar locations on these molecules and corresponded to experimentally identified epitopes on Bos d 2. The results suggest that human endogenous lipocalins could be involved in the modulation of immune responses against exogenous lipocalin allergens. In addition, our findings are likely to facilitate the development of new forms of immunotherapy against allergies induced by the important group of lipocalin allergens.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 018142730

Download citation: RISBibTeXText

Related references

Determination of the T cell epitopes of the lipocalin allergen, Rat n 1. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 34(12): 1919-1925, 2004

Anaplasma marginale major surface protein 2 CD4+-T-cell epitopes are evenly distributed in conserved and hypervariable regions (HVR), whereas linear B-cell epitopes are predominantly located in the HVR. Infection and Immunity 72(12): 7360-7366, 2004

B-cell epitopes in HIV-1 Tat and Rev proteins colocalize with T-cell epitopes and with functional domains. Biomedicine and Pharmacotherapy 51(10): 480-487, 1997

Significance of the intramolecular disulfide bond for the IgE epitopes of Bos d 2, a lipocalin allergen. Journal of Allergy and Clinical Immunology 101(1 Part 2): S49, 1998

Identification of T-cell epitopes without B-cell activity in the first and second conserved regions of the HIV Env protein. Aids 5(6): 699-707, 1991

Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. Journal of Biological Chemistry 275(28): 21572-21577, 2000

T cell epitopes in coxsackievirus B4 structural proteins concentrate in regions conserved between enteroviruses. Virology 293(2): 217-224, 2002

Identification of two t cell specific epitopes in the conserved regions of human immunodeficiency virus glycoprotein. Ginsberg, H , Et Al (Ed ) Vaccines (Cold Spring Harbor), 88 New Chemical And Genetic Approaches to Vaccination: Prevention Of Aids And Other Viral, Bacterial And Parasitic Diseases; Conference, Cold Spring Harbor, New York, Usa, September 9, 1987 Xxiii+396p Cold Spring Harbor Laboratory: Cold Spring Harbor, New York, Usa Illus Paper 357-360, 1988

The capsid gene of feline calicivirus contains linear B-cell epitopes in both variable and conserved regions. Journal of Virology 73(10): 8496-8502, 1999

Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40(7): 1950-1962, 2010

Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein. Journal of Immunology 155(4): 2232-2239, 1995

Antibodies which mediate hiv specific antibody dependent cell mediated cytotoxicity recognize epitopes within conserved regions of gp 160. Clinical Research 37(2): 557A, 1989

Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection. Journal of Immunology 169(2): 952-957, 2002

Identification of T and B cell epitopes from conserved regions of Plasmodium falciparum merozoite surface protein-1 through population studies in the Ivory Coast. 9TH INTERNATIONAL CONGRESS OF IMMUNOLOGY Author The 9th International Congress of Immunology : 808, 1995

Influences of HLA DRB1, DQA1 and DQB1 on T-cell recognition of epitopes and of larger regions of the botulinum neurotoxin molecule. Immunology Letters 190: 257-264, 2017