T-antigen is not bound to the replication origin of the simian virus 40 late transcription complex
T-antigen is not bound to the replication origin of the simian virus 40 late transcription complex
Hadlock, K.G.; Lutter, L.C.
Journal of Molecular Biology 215(1): 53-65
1990
ISSN/ISBN: 0022-2836
PMID: 2168948
DOI: 10.1016/s0022-2836(05)80094-4
Simian virus 40 tumor antigen (T-antigen) plays a central role in determining which gene is transcribed from viral DNA late in infection. Results from several studies have led to a model in which the binding of T-antigen to the viral origin of replication results in repression of transcription from the stronger early gene promoter and stimulation of transcription from the late gene promoter.