+ Translate
+ Most Popular
Investigations on the organic drift in North Swedish streams
Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research
Phloem necrosis of coffee in Surinam
Anatomy of Mystus seenghala IV Nervous system
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Tetrapleure (Tetrapleura tetraptera), an unknown African medicinal and spice plant
The origin and phylogenetic significance of the trochophoran larvae 2. evolutionary significance of the larvae of coelomate worms and mollusks
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Enterobacter amnigenus. An unusual human pathogen
Influence of Seriboost foliar application on leaf yield and leaf protein content in mulberry (Morus spp.), in relation to silkworm cocoon production
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
'Pan-sukh' disease of Rice in the Central Provinces
Geological age of the Ptilophyllum flora; a critical reassessment
Study of vitellogenesis in birds; physiological phases & role of folliculin in vitellogenesis
Evaluation of WCT coconut and Komadan coconut
Therapy for acne with saccharomyces boulardii
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Manufacture of Ricotta cheese from whey fortified with skim milk powder using different acidulants
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
Factors affecting fruitfulness in durian (Durio zibethinus Murr.). I. Flowering and pollination
Bronchial cuff pressure change caused by left-sided double-lumen endobronchial tube displacement
Some Biological Applications of Organometallic Compounds
The composition of pampas-grass (Cortaderia argentea.)

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies

Journal of Immunology 165(9): 5084-5096

ISSN/ISBN: 0022-1767

PMID: 11046039

DOI: 10.4049/jimmunol.165.9.5084

TNFR-associated factors (TRAFs) constitute a family of adapter proteins that associate with particular TNF family receptors. Humans and mice contain six TRAF genes, but little is known about their in vivo expression at the single cell level. The in vivo locations of TRAF1, TRAF2, TRAF5, and TRAF6 were determined in human and mouse tissues by immunohistochemistry. Striking diversity was observed in the patterns of immunostaining obtained for each TRAF family protein, suggesting their expression is independently regulated in a cell type-specific manner. Dynamic regulation of TRAFs was observed in cultured PBLs, where anti-CD3 Abs, mitogenic lectins, and ILs induced marked increases in the steady-state levels of TRAF1, TRAF2, TRAF5, and TRAF6. TRAF1 was also highly inducible by CD40 ligand in cultured germinal center B cells, whereas TRAF2, TRAF3, TRAF5, and TRAF6 were relatively unchanged. Analysis of 83 established human tumor cell lines by semiquantitative immunoblotting methods revealed tendencies of certain cancer types to express particular TRAFs. For example, expression of TRAF1 was highly restricted, with B cell lymphomas consistently expressing this TRAF family member. Consistent with results from tumor cell lines, immunohistochemical analysis of 232 non-Hodgkin lymphomas revealed TRAF1 overexpression in 112 (48%) cases. TRAF1 protein levels were also elevated in circulating B cell chronic lymphocytic leukemia specimens (n = 49) compared with normal peripheral blood B cells (p = 0.01), as determined by immunoblotting. These findings contribute to an improved understanding of the cell-specific roles of TRAFs in normal tissues and provide evidence of altered TRAF1 expression in lymphoid malignancies.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 018143725

Download citation: RISBibTeXText

Related references

Molecular cloning of feline tumour necrosis factor receptor type I (TNFR I) and expression of TNFR I and TNFR II in lymphoid cells in cats. European Journal of Immunogenetics: Official Journal of the British Society for Histocompatibility and Immunogenetics 30(2): 107-113, 2003

Expression of pro-apoptotic Bcl-2 family protein bad in normal hemato-lymphoid tissues and human tumor lines. Blood 90(10 Suppl. 1 Part 1): 53A, 1997

Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kB and AP-1. The Journal of Biological Chemistry 272: 029-32, 1997

Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. Journal of Biological Chemistry 272(22): 14029-14032, 1997

Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Annals of Oncology: Official Journal of the European Society for Medical Oncology 8 Suppl. 2: 101-104, 1997

Changes in the expression of tumor necrosis factor (TNF) alpha, TNFalpha receptor (TNFR) 2, and TNFR-associated factor 2 in granulosa cells during atresia in pig ovaries. Biology of Reproduction 68(2): 530-535, 2003

Changes in the Expression of Tumor Necrosis Factor (Tnf) , Tnf Receptor (Tnfr) 2, and Tnfr-Associated Factor 2 in Granulosa Cells During Atresia in Pig Ovaries. Biology of Reproduction 68(2): 530-535, 2002

BCL7A protein expression in normal and malignant lymphoid tissues. British Journal of Haematology 160(1): 106-109, 2013

Expression of Bcl-2 protein and Bcl-2 mRNA in normal and neoplastic lymphoid tissues. Leukemia and Lymphoma 13(1-2): 81-87, 1994

Platelet-derived endothelial cell growth factor/thymidine phosphorylase immunohistochemical expression in lymphoid tissue and lymphoid malignancies. Human Pathology 28(10): 1146-1151, 1997

Id1 and Id2 expression in human normal lymphoid tissues and lymphoid neoplasia. FASEB Journal 10(6): A1148, 1996

Expression and phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 in B-cell lymphomas and reactive lymphoid tissues. Archives of Pathology and Laboratory Medicine 135(3): 365-371, 2011

Further analysis of tumor necrosis factor receptor tnfr expression in human epidermal cells evidence that langerhans cells lc differ from keratinocytes by expressing both the 55 kd and the 75 kd tnfr. Journal of Investigative Dermatology 98(4): 565, 1992

Inhibition of protein kinase C arrests cell growth, induces apoptosis, and alters the effect of basic fibroblast growth factor on bcl-2 expression in chronic lymphoid malignancies. Blood 88(10 Suppl. 1 Part 1-2): 67A, 1996

Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society 45(7): 1005-1019, 1997