+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Targeting disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues



Targeting disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues



The Journal of Biological Chemistry 277(28): 323-8




Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 018144769

Download citation: RISBibTeXText


Related references

Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues. Journal of Biological Chemistry 277(28): 25323-8, 2002

Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. Journal of Biological Chemistry 275(49): 38319-38328, 2000

Regulation of spermidine/spermine N-1-acetyltransferase by intracellular polyamine pools: Evidence for a functional role in polyamine homeostasis. FEBS (Federation of European Biochemical Societies) Letters 321(2-3): 179-183, 1993

Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging. Journal of Cellular and Molecular Medicine 10(4): 933-945, 2006

Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N-1-acetyltransferase activity and cell proliferation. Cancer Letters. 95(1-2): 247-252, 1995

Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. Biochemical Journal 358(Pt 1): 137-145, 2001

Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine. Molecular Pharmacology 55(4): 693-698, 1999

Major increases in spermidine/spermine-N1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells. Cancer Research 49(22): 6226-6231, 1989

Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. Journal of Biological Chemistry 268(25): 19118-19125, 1993

Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Biochemical Journal 422(1): 101-109, 2009

Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues. Cancer Research 49(14): 3829-3833, 1989

Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest. American Journal of Physiology. Cell Physiology 292(3): C1204-C1215, 2007

Relationship between cytotoxicity and superinduction of spermidine/spermine N1-acetyltransferase Effect of polyamine analogues. Human & Experimental Toxicology 17(1): 55, 1998

The identification of a cis-element and a trans-acting factor involved in the response to polyamines and polyamine analogues in the regulation of the human spermidine/spermine N1-acetyltransferase gene transcription. Journal of Biological Chemistry 273(51): 34623-34630, 1998

Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase. Molecular Cancer Therapeutics 3(7): 813-822, 2004