EurekaMag
+ Translate
+ Most Popular
Investigations on the organic drift in North Swedish streams
Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research
Phloem necrosis of coffee in Surinam
Anatomy of Mystus seenghala IV Nervous system
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Tetrapleure (Tetrapleura tetraptera), an unknown African medicinal and spice plant
The origin and phylogenetic significance of the trochophoran larvae 2. evolutionary significance of the larvae of coelomate worms and mollusks
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Enterobacter amnigenus. An unusual human pathogen
Influence of Seriboost foliar application on leaf yield and leaf protein content in mulberry (Morus spp.), in relation to silkworm cocoon production
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
'Pan-sukh' disease of Rice in the Central Provinces
Geological age of the Ptilophyllum flora; a critical reassessment
Study of vitellogenesis in birds; physiological phases & role of folliculin in vitellogenesis
Evaluation of WCT coconut and Komadan coconut
Therapy for acne with saccharomyces boulardii
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Manufacture of Ricotta cheese from whey fortified with skim milk powder using different acidulants
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
Factors affecting fruitfulness in durian (Durio zibethinus Murr.). I. Flowering and pollination
Bronchial cuff pressure change caused by left-sided double-lumen endobronchial tube displacement
Some Biological Applications of Organometallic Compounds
The composition of pampas-grass (Cortaderia argentea.)

Testosterone response of cryptorchid and hypophysectomized rats to human chorionic gonadotrophin (hCG) stimulation


Testosterone response of cryptorchid and hypophysectomized rats to human chorionic gonadotrophin (hCG) stimulation



Australian Journal of Biological Sciences 38(4): 445-455



ISSN/ISBN: 0004-9417

PMID: 2871828

DOI: 10.1071/bi9850445

The testosterone responses to a single injection of hCG (100 i.u.) in hypophysectomized (hypox.), cryptorchid or sham-operated rats were followed over a 5-day period. In sham-operated rats, hCG induced a biphasic rise in serum testosterone, peaks being observed at 2 and 72 h. Reduced testis weights, elevated FSH and LH levels and reduced serum testosterone levels were found after 4 weeks of cryptorchidism, but hCG stimulation resulted in a normal 2 h peak in serum testosterone. However, the secondary rise at 72 h in cryptorchid rats was significantly lower than sham-operated rats. Reduced testis weight and undetectable serum FSH and LH levels together with decreased testosterone levels were found 4 weeks after hypophysectomy. Serum testosterone levels rose 2 h after hCG in comparison to hypox. controls but this peak was significantly reduced compared with sham-operated rats. The second rise in serum testosterone began on day 2, peaking on day 4 at levels comparable to that seen in sham-operated rats after hCG. The in vitro basal and hCG stimulated secretion of testosterone by cryptorchid testes was greater than that secreted by normal rat testes (518.0 +/- 45.9 and 3337.6 +/- 304.1 pmol per testis per 4 h compared with 223.6 +/- 24.9 and 1312.9 +/- 141.4 pmol per testis per 4 h for normal rat testes). In cryptorchid animals a single injection of 100 i.u. hCG resulted in a pattern of in vitro refractoriness similar to normal rats, lasting from 12 h to 2 days, during which testosterone secretion was reduced to near basal levels. The in vitro basal and hCG-stimulated secretion of testosterone by hypox. rat testes was severely diminished compared with normal rat testes. The temporal pattern of in vitro secretion of testosterone from hypox. rat testes mimicked the in vivo serum testosterone pattern seen in these animals. This study demonstrates important differences in the in vivo and in vitro testosterone response to hCG after testicular damage.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 018147252

Download citation: RISBibTeXText

Related references

Testosterone response of cryptorchid and hypophysectomized rats to human chorionic gonadotropin stimulation. Australian Journal of Biological Sciences 38(4): 445-456, 1985

Testosterone concentrations in normal and cryptorchid horses. Response to human chorionic gonadotrophin. Animal Reproduction Science 18(1-3): 43-50, 1989

Long term replacement therapies with testosterone propionate and human chorionic gonadotrophin in hypophysectomized adult male rats. Experientia 26(8): 911-914, 1970

Human chorionic gonadotrophin (HCG) stimulation test and testosterone response in children with micropenis. Pediatric Endocrinology Reviews: Per 12(1): 42-45, 2014

Testicular blood flow, vascular permeability, and testosterone production after stimulation of unilaterally cryptorchid adult rats with human chorionic gonadotropin. Endocrinology 117(5): 1906-1913, 1985

Pattern of the response to human chorionic gonadotropin stimulation in pre pubertal cryptorchid boys plasma levels of testosterone and its precursors delta 4 androstenedione and 17 alpha hydroxy progesterone. Job, J-C (Ed ) Pediatric And Adolescent Endocrinology, Vol 6 Cryptorchidism: Diagnosis And Treatment Vi+228p S Karger: Basel, Switzerland; New York, N Y , Usa Illus Paper P108-120, 1979, 1980

Dose-response effects of equine chorionic gonadotrophin and human chorionic gonadotrophin on early embryonic development and viable pregnancy rate in rats. Reproduction (Cambridge) 122(2): 283-287, 2001

Dose-response effects of equine chorionic gonadotrophin (eCG) and human chorionic gonadotrophin (hCG) on early embryonic development and viable pregnancy rate in rats. Reproduction 122(2): 283-287, 2001

The Icsh Effect of Human Post-Menopausal Gonadotrophin on the Ovary of Hypophysectomized Immature Rats and Intact Immature Mice at 21 and 24 Days of Age (Alone or in Combination with Human Chorionic Gonadotrophin). Folia endocrinologica 16: 562-576, 1963

Differences in testosterone, androstenone, and skatole levels in plasma and fat between pubertal purebred Duroc and Landrace boars in response to human chorionic gonadotrophin stimulation. Theriogenology 74(6): 1088-1098, 2010

Effect of human chorionic gonadotrophin on the uterus and ovaries of hypophysectomized rats. Journal of Endocrinology 46(2): 177-183, 1970

Levels of testosterone and luteinizing hormone in the plasma of young post-pubertal bulls after injection of human chorionic gonadotrophin or dexamethasone and human chorionic gonadotrophin. Journal of Endocrinology 75(3): 451-452, 1977

Gubernacular fibroblasts express the androgen receptor during testis descent in cryptorchid rats treated with human chorionic gonadotrophin. Urological Research 32(6): 386-390, 2004

Action of human chorionic gonadotrophin vivo upon microsomal enzymes in testes of hypophysectomized rats. Biochimica et Biophysica Acta - General Subjects 141(2): 433-435, 1967

Action of human chorionic gonadotrophin in vivo upon microsomal enzymes in testes of hypophysectomized rats. Biochimica et Biophysica Acta 141(2): 433-435, 1967