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The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function


The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function



Journal of Cell Biology 99(2): 373-377



ISSN/ISBN: 0021-9525

PMID: 6746733

DOI: 10.2307/1611130

Aminoacyl-tRNA synthetases from eucaryotic cells generally are isolated as high molecular weight complexes comprised of multiple synthetase activities, and often containing other components as well. A model is proposed for the synthetase complex in which hydrophobic extensions on the proteins serve to maintain them in their high molecular weight form, but are not needed for catalytic activity. The structural similarity of these enzymes to certain membrane-bound proteins, and its implications for synthetase localization and function in vivo, are discussed.

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Accession: 018167318

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