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The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

Experimental Cell Research 181(2): 305-316

ISSN/ISBN: 0014-4827

PMID: 2647496

DOI: 10.1016/0014-4827(89)90090-6

Alterations of the balanced supply of the precursors of DNA synthesis, the deoxyribonucleoside triphosphates, have dramatic genetic consequences for mammalian cells including the induction of mutations, the sensitization to DNA damaging agents, and the production of gross chromosomal abnormalities. The use of recombinant DNA techniques has allowed the analysis of some of these effects and has revealed further mechanisms by which mammalian cells control the accuracy of DNA replication.

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Accession: 018173379

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