EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The mouse muscle creatine kinase cDNA and deduced amino acid sequences: comparison to evolutionarily related enzymes



The mouse muscle creatine kinase cDNA and deduced amino acid sequences: comparison to evolutionarily related enzymes



Journal of Molecular Evolution 22(4): 334-341



The nucleotide sequence of cloned DNA corresponding to full-length mouse muscle creatine kinase mRNA has been determined. This 1415 base pair DNA sequence and the deduced 381 amino acid sequence of the protein have been compared to creatine kinase sequences from other vertebrate species and to invertebrate guanidino kinase sequences. These comparisons show that the vertebrate muscle creatine kinases constitute a remarkably conserved protein family with a unit evolutionary period of 30. The creatine kinases also retain marked sequence similarity with the more distantly related invertebrate guanidino kinases. A portion of the sequence, presumably part of the ATP binding site, shows similarity to other nucleotide binding proteins with diverse functions. Comparisons of the untranslated regions of the creatine kinase cDNA sequences show that the 5' untranslated regions are more highly conserved than are the 3' untranslated regions; this may point to some regulatory function in the 5' region.

(PDF same-day service: $19.90)

Accession: 018173602

Download citation: RISBibTeXText

PMID: 3003372

DOI: 10.1007/bf02115689



Related references

The mouse muscle creatine kinase complementary dna and deduced amino acid sequences comparison to evolutionarily related enzymes. Journal of Molecular Evolution 22(4): 334-341, 1985

Snake Muscle Creatine Kinase cDNA Molecular Cloning, Expression and Comparison with Evolutionarily Related Enzymes. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica 32(5): 469-474, 2002

Gene duplication events producing muscle (M) and brain (B) isoforms of cytoplasmic creatine kinase: cDNA and deduced amino acid sequences from two lower chordates. Molecular Biology and Evolution 18(7): 1305-1314, 2001

CDNA and deduced amino acid sequences for a dimeric creatine kinase from a protostome. American Zoologist 38(5): 124A, 1998

CDNA and deduced amino acid sequences for an octameric creatine kinase from a protostome. American Zoologist 39(5): 73A, 1999

Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes. Biochemical Journal 269(2): 335-340, 1990

Complete cDNA-derived amino acid sequence of chick muscle creatine kinase. Journal of Biological Chemistry 259(24): 15224-7, 1984

Comparison of amino acid sequences deduced from a cDNA fragment obtained from infectious pancreatic necrosis virus (IPNV) strains of different serotypes. Virology 195(2): 840-844, 1993

The amino acid sequence of the peptide containing the thiol group of creatine kinase from normal and dystrophic chicken breast muscle. Comparison of some of the immunological properties of the antibodies developed in rabbits against these enzymes. Biochemical Journal 143(1): 171-179, 1974

Porcine guanylin and uroguanylin: cDNA sequences, deduced amino acid sequences, and biological activity of the chemically synthesized peptides. Biochemical and Biophysical Research Communications 259(1): 141-148, 1999

Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences. Nucleic Acids Research 17(2): 802-802, 1989

cDNA and deduced amino acid sequences of dog catalase. Dna Sequence 9(5-6): 347-352, 1999

Estimation of creatine kinase iso enzymes the effects of caffeine and retinoic acid on creatine kinase levels in fetal mouse limbs. Toxicology Letters (Shannon) 21(3): 339-348, 1984

cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). Nucleic Acids Research 17(12): 4888-4888, 1989