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The negative effects of bile acids and tumor necrosis factor-a on the transcription of cholesterol 7a-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors


The negative effects of bile acids and tumor necrosis factor-a on the transcription of cholesterol 7a-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors



The Journal of Biological Chemistry 276(33): 708-16




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The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. Journal of Biological Chemistry 276(33): 30708-30716, 2001

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