The patch clamp is more useful than anyone had expected
The patch clamp is more useful than anyone had expected
Sigworth, F.J.
Federation Proceedings 45(12): 2673-2677
1986
ISSN/ISBN: 0014-9446
PMID: 2429870
The patch clamp was developed into its present form by Neher and Sakmann for recording the currents through individual ionic channels in excitable membranes. Recent advances now allow the patch-clamp technique to be used to record from cell-free membrane patches and from entire small cells. The technique has been used extensively for recordings from single channels that have provided new insights into their functioning; it is also being applied to a surprising variety of other physiological problems.