+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Thermal, mechanical and chemical peripheral sensation in amphibians: opioid and adrenergic effects

Thermal, mechanical and chemical peripheral sensation in amphibians: opioid and adrenergic effects

Life Sciences 58(2): 5-33

ISSN/ISBN: 0024-3205

DOI: 10.1016/0024-3205(95)02265-1

The acetic acid test (AAT) is a quantifiable assay of the response to noxious chemical stimuli on the hindlimb of the northern grass frog, Rana pipiens. AAT is sensitive to both opioid and adrenergic agonist modulation. The present study introduces the novel use of mechanical and thermal stimulus behavioral assays in comparison with the established acetic acid test in studying nociception in frogs. We evaluated mechanical and thermal responses and their sensitivity to systemic morphine (MOR) or dexmedetomidine (DEX) administrations with comparison to AAT. MOR produced dose-related elevations of response thresholds in all three sensory tests, whereas DEX produced elevations in the thermal and AAT assays but had no effect on sensitivity to non-noxious mechanical stimuli. The results suggest a distinct separation of sensory modalities in the frog similar to that observed in mammals and indicate the usefulness of this amphibian model in further studies of nociception.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 018183199

Download citation: RISBibTeXText

Related references

Thermal, mechanical and chemical peripheral sensation in amphibians: opioid and adrenergic effects. Life Sciences 58(2): 125-133, 1996

Spinal m, c and k opioids alter chemical, mechanical and thermal sensitivities in amphibians. Life Sciences 61(22): 67-76, 1997

Spinal mu, delta and kappa opioids alter chemical, mechanical and thermal sensitivities in amphibians. Life Sciences 61(22): 2167-2176, 1997

Spinal opioid pharmacology in the frog Chemical, thermal and mechanical sensitivities. Society for Neuroscience Abstracts 22(1-3): 1366, 1996

(-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice. Molecular Pain 7: 23, 2011

Delta-opioid receptors mediated control of substance P release in the dorsal horn of the rat following mechanical or thermal noxious peripheral stimulation. Society for Neuroscience Abstracts 20(1-2): 963, 1994

Analgesic action of opioid and adrenergic agents in amphibians. FASEB Journal 8(4-5): A629, 1994

Thermal sensation and the skin sensation test: regional differences and their effects on the issue of reliability of temperature ranges. Australian Journal of PhysioTherapy 34(2): 89-93, 1988

Effects of transdermal lidocaine or lidocaine with prilocaine or tetracaine on mechanical superficial sensation and nociceptive thermal thresholds in horses. Veterinary Anaesthesia and Analgesia 45(2): 227-233, 2018

Abolished thermal and mechanical antinociception but retained visceral chemical antinociception induced by butorphanol in mu-opioid receptor knockout mice. Neuropharmacology 54(8): 1182-1188, 2008

Hierarchical Bayesian modeling for predicting ordinal responses of personalized thermal sensation: Application to outdoor thermal sensation data. Building and Environment 142: 414-426, 2018

Effects of peripheral κ opioid receptor activation on inflammatory mechanical hyperalgesia in male and female rats. Neuroscience Letters 524(2): 111-115, 2012

Peripheral neural mechanisms of thermal sensation. Dubner, Ronald And Yojiro Kawamura (edited By)facial Sensory And Motor Mechanisms. Ix: New York, N.y., U.s.a. 7-22, 1971

Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats. Psychopharmacology 148(2): 180-185, 2000

Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors. Neuropharmacology 135: 328-342, 2018