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Topological analysis of the reovirus type 3 hemagglutinin

Topological analysis of the reovirus type 3 hemagglutinin

Virology 127(1): 220-224

We previously showed that the reovirus type 3 hemagglutinin (HA) has distinct functional domains. For example, we identified one group of anti-HA monoclonal antibodies which only inhibited virus-mediated hemagglutination and another group which exclusively neutralized reovirus infectivity. Using competition radioimmunoassays, we now report that these functionally discrete domains on the reovirus type 3 HA correspond to discrete antigenic regions of the protein.

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Accession: 018187238

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PMID: 6858002

DOI: 10.1016/0042-6822(83)90385-9

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