+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

trans-repression of the mouse c-fos promoter: a novel mechanism of Fos-mediated trans-regulation



trans-repression of the mouse c-fos promoter: a novel mechanism of Fos-mediated trans-regulation



Cell 59(6): 999-1007



Fos protein can trans-activate AP-1-dependent gene expression and trans-repress the c-fos promoter. Although we find that trans-repression is enhanced by coexpression of c-Jun, it does not require any of the AP-1 or ATF sites in the mouse c-fos promoter. A major target for repression is the serum response element (SRE). Fos mutants with an impaired leucine zipper are defective in trans-repression and transformation, suggesting that these functions involve the formation of Fos protein complexes. In contrast, mutations that abolish DNA binding of Fos enhance trans-repression but destroy the transforming potential of Fos. In addition, v-Fos protein efficiently transforms but is unable to trans-repress. These findings point to different mechanisms involved in trans-activation and trans-repression and suggest that trans-repression of the type described here is neither sufficient nor required for Fos-induced transformation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 018188841

Download citation: RISBibTeXText

PMID: 2513130

DOI: 10.1016/0092-8674(89)90756-3


Related references

Repression de repression trans inhibition and trans stimulation of amino acid transport in rat hepatocytes and 4 rat hepatoma cell lines in culture. Journal of Biological Chemistry 254(14): 6691-6697, 1979

Repression of 72kDa type IV collagenase expression by ATF3 via a mechanism in which p53-dependent trans-activation of the collagenase promoter is diminished. Proceedings of the American Association for Cancer Research Annual Meeting 43: 812, 2002

Kinetics and mechanism for reduction of the anticancer prodrug trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (JM335) by thiols. Inorganic Chemistry 39(8): 1728-1734, 2003

Steroid ligands of androgen binding protein. The enantiomers of trans-trans and cis-trans perhydrohexestrols and trans-trans perhydrodiketones. Journal of Steroid Biochemistry 17(1): 101-112, 1982

Density functional theory study of the trans-trans-cis (TTC)-->trans-trans-trans (TTT) isomerization of a photochromic spiropyran merocyanine. Molecules 13(6): 1246-1252, 2008

Activity of mouse liver glutathione S-transferases toward trans,trans-muconaldehyde and trans-4-hydroxy-2-nonenal. Toxicology and Applied Pharmacology 119(2): 175-180, 1993

Repression by homeoprotein pitx1 of virus-induced interferon a promoters is mediated by physical interaction and trans repression of IRF3 and IRF7. Molecular and Cellular Biology 22(20): 7120-7133, 2002

Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism. Molecular Cancer Therapeutics 11(9): 1894-1904, 2013

A novel lncRNA-mediated trans-regulatory mechanism in the development of cleft palate in mouse. Molecular Genetics & Genomic Medicine 2018, 2018

Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. Embo Journal 13(22): 5451-5459, 1994

Loss of trans-activation with retained trans-repression determines dominant-negative effect of mutant p53. Proceedings of the American Association for Cancer Research Annual Meeting (41): 743, 2000

Quantitative structure-antioxidant activity relationship of trans-resveratrol oligomers, trans-4,4'-dihydroxystilbene dimer, trans-resveratrol-3-O-glucuronide, glucosides: trans-piceid, cis-piceid, trans-astringin and trans-resveratrol-4'-O-beta-D-glucopyranoside. European Journal of Medicinal Chemistry 45(6): 2366-2380, 2010

Regulation of function of the murine luteinizing hormone receptor promoter by cis- and trans-acting elements in mouse Leydig tumor cells. Molecular & Cellular Endocrinology 119(2): 207-217, 1996

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Molecular and Cellular Biology 22(10): 3373-3388, 2002

trans-Repression of protein expression dependent on the Epstein-Barr virus promoter Wp during latency. Journal of Virology 85(21): 11435-11447, 2011