EurekaMag
+ Translate
+ Most Popular
Sympathetic and visceral nerve blocks
What should be done after bee or wasp stings?
Anti-drool cheiloplasty: clinical results in six dogs
The biology of human starvation: some new insights
Vitamin B12 deficiency as a worldwide problem
Effect of daily gelatin ingestion on human scalp hair
On the nature and role of vivotoxins in plant disease
History of the discovery of vitamins by N. I. Lunin
Preliminary tests with residual sprays against poultry lice
MDU.1, a new mutant chilli variety
A study on compatibility of some insecticides with a fungicide on small cardamom (Elettaria cardamomum Maton.)
The cranial nerves of Mystus seenghala (Sykes)
The effects of prefrontal lobotomy on aggressive behavior in dogs
Human monkeypox: disease pattern, incidence and attack rates in a rural area of northern Zaire
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Therapy for acne with saccharomyces boulardii
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
The composition of pampas-grass (Cortaderia argentea.)
Productivity of Pekin x Khaki Campbell ducks
A rapid survey of katydids (Insecta: Orthoptera: Tettigoniidae) of the Foret Classee du Pic de Fon, Guinea
Cranial nerves of Labeo rohita (Ham.)
Evaluating fundamentals of care: The development of a unit-level quality measurement and improvement programme
Life-cycle of the free-living nematode Pontonema vulgare in the White Sea
Grey leaf blight - a new disease of cocoa
Effect of foliar spray of urea and zinc sulphate on yield and fruit quality of Kinnow - 'a mandarin hybrid'

Transfer of proteins into mitochondria. Precursor to the ADP/ATP carrier binds to receptor sites on isolated mitochondria


Transfer of proteins into mitochondria. Precursor to the ADP/ATP carrier binds to receptor sites on isolated mitochondria



Journal of Biological Chemistry 258(7): 4071-4074



ISSN/ISBN: 0021-9258

PMID: 6300074

The precursor form of Neurospora crassa mitochondrial ADP/ATP carrier synthesized in a cell-free protein-synthesizing system can be imported into isolated mitochondria. If the mitochondrial transmembrane potential is abolished, import does not occur but the precursor binds to the mitochondrial surface. Upon reestablishment of the membrane potential, the bound precursor is imported. This occurs without dissociation of the bound precursor from the mitochondrial surface. We conclude that the binding observed represents an interaction with receptor sites and thus is an early step in the import pathway.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 018190263

Download citation: RISBibTeXText

Related references

Transport of proteins into mitochondria. Posttranslational transfer of ADP/ATP carrier into mitochondria in vitro. European Journal of Biochemistry 109(1): 217-229, 1980

Import of proteins into mitochondria. Isolated yeast mitochondria and a solubilized matrix protease correctly process cytochrome c oxidase subunit V precursor at the NH2 terminus. Journal of Biological Chemistry 258(8): 4944-4949, 1983

Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site. Journal of Cell Biology 107(6 Pt 2): 2483-2490, 1988

Part 2 || Import Pathways of Precursor Proteins into Mitochondria: Multiple Receptor Sites Are Followed by a Common Membrane Insertion Site. Journal of Cell Biology 107(6): 2483-2490, 1988

Translocation of proteins into rat liver mitochondria. Existence of two different precursor polypeptides of liver fumarase and import of the precursor into mitochondria. Journal of Biological Chemistry 260(6): 3402-3407, 1985

Thyroid hormones binds three distinct proteins in isolated rat liver mitochondria. FASEB Journal 9(3): A397, 1995

Amyloid precursor protein, heat-shock proteins, and Bcl-2 form a complex in mitochondria and modulate mitochondria function and apoptosis in N2a cells. Mechanisms of Ageing and Development 130(9): 592-601, 2009

Import of precursor proteins into isolated yeast mitochondria. Methods in Molecular Biology 313: 373-383, 2006

Translocation of proteins into rat liver mitochondria. The precursor polypeptides of a large subunit of succinate dehydrogenase and ornithine aminotransferase and their imports into their own locations of mitochondria. European Journal of Biochemistry 155(3): 543-549, 1986

Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria. Molecular Biology of the Cell 20(5): 1400-1407, 2009

Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria. Journal of cell biology 121(6): 1233-1243, 1993

Sorting of precursor proteins between isolated spinach leaf mitochondria and chloroplasts. Plant Molecular Biology 14(6): 977-982, 1990

Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria. Biochimica et Biophysica Acta 974(1): 1-23, 1989

Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria. Journal of Biological Chemistry 257(21): 13034-13041, 1982

Exploration of the nucleotide binding sites of the isolated ADP/ATP carrier protein from beef heart mitochondria. 1. Probing of the nucleotide sites by Naphthoyl-ATP, a fluorescent nontransportable analogue of ATP. Biochemistry 21(25): 6343-6347, 1982