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Two-dimensional NMR and protein structure


Two-dimensional NMR and protein structure



Annual Review of Biochemistry 58: 223-256



ISSN/ISBN: 0066-4154

PMID: 2673010

DOI: 10.1146/annurev.bi.58.070189.001255

The possibility of an autoimmune mechanism of pathogenesis in amyotrophic lateral sclerosis has long been considered, but the evidence to support a conventional autoimmune process, reviewed here, is inconclusive. However, antibodies that react in vitro with gangliosides have recently been found in sera of a large majority of patients with classical amyotrophic lateral sclerosis and other motor neuron syndromes.

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Accession: 018195945

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