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Use of blood outgrowth endothelial cells as virus-producing vectors for gene delivery to tumors

Use of blood outgrowth endothelial cells as virus-producing vectors for gene delivery to tumors

American Journal of Physiology. Heart and Circulatory Physiology 287(2): H494-H500

ISSN/ISBN: 0363-6135

PMID: 15277193

DOI: 10.1152/ajpheart.00064.2004

Cell-based delivery of therapeutic viruses has potential advantages over systemic viral administration, including attenuated neutralization and improved viral targeting. One of the exciting new areas of investigation is the potential ability of endothelial-lineage cells to deliver genes to the areas of neovascularization.

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Accession: 018200695

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