+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Voltage dependence and barium sensitivity of colonic K secretion in renal failure

Voltage dependence and barium sensitivity of colonic K secretion in renal failure

American Journal of Physiology 256(3 Part 2): F490-F496

ISSN/ISBN: 0002-9513

PMID: 2923226

DOI: 10.1152/ajprenal.1989.256.3.f490

Net colonic K secretion (JKnet) is increased in rats and humans with chronic renal failure (CRF). To study whether transepithelial potential difference (PD), active transport forces and/or luminal K conductance play a role in this adaptation, experiments were performed in the colon of control, K-adapted, and CRF rats. Under basal conditions the PD in vivo in CRF was greater than in controls and not different from K-adapted rats. JKnet was comparable in vivo in CRF and K-adapted rats and was greater than in controls. Amiloride (10 microM) reduced PD and JKnet in K-adapted and CRF rats to levels comparable to controls. Under in vitro short-circuited conditions serosal-to-mucosal K flux (JKs----m) in distal colon was significantly increased in K-adapted and CRF animals compared with control, whereas barium caused a significant reduction in JKs----m in all groups of animals. The barium-sensitive component of K secretion was greater, however, in the two experimental groups (-0.2 +/- 0.02 and -0.2 +/- 0.07 in K-adapted and CRF animals, respectively, vs. -0.08 +/- 0.02 in controls, P less than 0.05). However, luminal barium failed to completely inhibit the increase in K secretion observed in the experimental groups. These data suggest that an increase in PD that results in a rise in luminal negativity, stimulation of active transport, and an increase in barium-sensitive K channels and barium-insensitive pathways in apical membrane of distal colon participate in the mechanism by which net K secretion is increased in the large intestine of subjects with CRF.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 018206637

Download citation: RISBibTeXText

Related references

Voltage dependence and barium sensitivity of colonic potassium secretion in renal failure. American Journal of Physiology 256(3 Part 2): F490-F496, 1989

Cyclooxygenase dependence of enhanced colonic potassium secretion in chronic renal failure. Journal of the American Society of Nephrology 5(3): 287, 1994

Renal transepithelial phosphate secretion: luminal membrane voltage and Ca2+ dependence. American Journal of Physiology 267(4 Part 2): F624-F631, 1994

Regulation of colonic K+ secretion in end-stage renal failure. Gut 46(11): A82, 2000

Voltage dependence of two inward currents carried by calcium and barium in the ciliate Stylonychia mytilus. Journal of Physiology 380: 551-574, 1986

Sensitivity of gastric acid secretion in patients with chronic renal failure. Scandinavian Journal of Gastroenterology 22(9): 1123-1129, 1987

Inactivation of the barium current in dissociated helix neurons voltage dependence and the role of phosphorylation. Pfluegers Archiv European Journal of Physiology 420(5-6): 470-478, 1992

Barium enema examination: sensitivity in detecting colonic polyps and carcinomas. Southern Medical Journal 82(2): 197-200, 1989

Voltage dependence of the actions of nifedipine and BAY K 8644 on barium currents recorded from single smooth muscle cells from the rabbit ear artery. Biomedica Biochimica Acta 46(8-9): S657-S661, 1987

Dependence of pituitary hormone secretion on the pattern of spontaneous voltage-gated calcium influx. Cell type-specific action potential secretion coupling. Journal of Biological Chemistry 276(36): 33840-33846, 2001

Colonic bicarbonate secretion effect of transepithelial voltage. Clinical Research 33(2 Part 1): 320A, 1985

Alterations in growth hormone secretion and clearance in peripubertal boys with chronic renal failure and after renal transplantation. Cooperative Study Group of Pubertal development in Chronic Renal Failure. Journal of Clinical Endocrinology and Metabolism 78(6): 1298-1306, 1994

Comparison between CT colonography and double-contrast barium enema for colonic evaluation in patients with renal insufficiency. Korean Journal of Radiology 13(3): 290-299, 2012

Voltage dependence of ATP secretion in mammalian taste cells. Journal of General Physiology 132(6): 731-744, 2008

Colonic retnetion of barium in the elderly after barium-meal examination and its treatment with lactulose. British Medical Journal 4(5839): 530-533, 1972