+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Silent celiac disease is frequent in the siblings of newly diagnosed celiac patients



Silent celiac disease is frequent in the siblings of newly diagnosed celiac patients



Digestion 75(4): 182-187



Celiac disease is caused by environmental and genetic factors, and the relatives of celiac patients are at higher risk of developing celiac disease than the general population. This prospective study evaluates the prevalence of celiac disease in the asymptomatic siblings of celiac patients. Forty-eight siblings (22 males; mean age 13 years) of 39 celiac children (20 males; mean age 4 years), and 120 siblings (55 males; mean age 33 years) of 55 adult celiac patients (12 males; mean age 31 years) were serologically screened for celiac disease. Positive cases were considered for endoscopic duodenal biopsies. Forty of the 168 asymptomatic siblings (23.8%) were affected by celiac disease. There were no differences between the index cases with and without affected siblings in terms of age at diagnosis, symptoms at onset, order of birth, associated disorders or other affected relatives. The male siblings of pediatric patients were affected in 40.9% of cases and female siblings in 26.9%; the corresponding figures for adults were 16.4 and 23.1%. Silent celiac disease is 24-48 times more frequent in the siblings of celiac patients than in the general population. No predictive factors for sibling involvement were found. Adult females seem to tolerate gluten less than adult males.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 020016881

Download citation: RISBibTeXText

PMID: 17848794

DOI: 10.1159/000107979


Related references

Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease Are Frequent and Linked With Autoimmunity to Transglutaminase 6. Clinical Gastroenterology and Hepatology 17(13): 2678-2686.E2, 2019

Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet--association with the grade of mucosal villous atrophy. American Journal of Clinical Nutrition 67(3): 482-487, 1998

Vitamin A levels are comparable between children with newly diagnosed coeliac disease and non-coeliac controls. Acta Paediatrica 108(11): 2095-2099, 2019

Concomitant autoantibodies in newly diagnosed diabetic children with transient celiac serology or proven celiac disease. Journal of Pediatric Endocrinology and Metabolism 26(11-12): 1099-1104, 2013

Risks for lymphoma and gastrointestinal carcinoma in patients with newly diagnosed adult-onset celiac disease: Consequences for follow-up: Celiac disease, lymphoma and GI carcinoma. United European Gastroenterology Journal 6(10): 1485-1495, 2018

Hypertransaminasemia in Newly Diagnosed Pediatric Patients With Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition 63(3): 340-343, 2016

Prevalence of celiac disease in siblings of Iranian patients with celiac disease. Arquivos de Gastroenterologia 48(2): 131-135, 2012

Prevalence of celiac disease in siblings of Iranian patients with celiac disease. Arquivos de Gastroenterologia 48(2): 131-135, 2011

Prevalence of celiac disease in first-degree siblings of celiac disease patients. Indian Journal of Gastroenterology 26(1): 46, 2007

Occurrence of celiac disease in siblings and offspring of patients with celiac disease. Casopis Lekaru Ceskych 140(22): 695-698, 2001

Prior endoscopy in patients with newly diagnosed celiac disease: a missed opportunity?. Digestive Diseases and Sciences 58(5): 1293-1298, 2013

Prevalence of celiac disease among siblings of celiac disease patients. Indian Journal of Gastroenterology 25(5): 233-235, 2006

Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients. American Journal of Clinical Pathology 138(1): 42-49, 2012

Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 5(10): 3975-3992, 2013

Is it necessary to assess for fat-soluble vitamin deficiencies in pediatric patients with newly diagnosed celiac disease?. Journal of Pediatric Gastroenterology and Nutrition 59(2): 225-228, 2014