+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cells migrating from the neural crest contribute to the innervation of the venous pole of the heart



Cells migrating from the neural crest contribute to the innervation of the venous pole of the heart



Journal of Anatomy 212(1): 1-11



Cells migrating from the neural crest are known to septate the outflow tract of the developing heart, and to contribute to the formation of the arterial valves, their supporting sinuses, the coronary arteries and cardiac neural ganglia. Neural crest cells have also been suggested to contribute to development of the venous pole of the heart, but the extent and fate of such cells remains unclear. In this study, in the mouse, it is shown that cells from the neural crest contribute to the parasympathetic and, to a lesser extent, the sympathetic innervation of the venous pole of the heart. Nerves within the venous pole of the heart are shown to be of mixed origin, with some being derived from the neural crest, while others have an alternative origin, presumably placodal. The neurons innervating the nodal tissue, which can exert chronotropic effects on cardiac conduction, are shown not to be derived from the neural crest. In particular, no evidence was found to support previous suggestions that cells from the neural crest make a direct contribution to the myocardial atrioventricular conduction axis, although a small subset of these cells do co-localize with the developing left bundle branch. We have therefore confirmed that cells from the neural crest migrate to the venous pole of the heart, and that their major role is in the development of the parasympathetic innervation. In addition, in some embryos, a population of cells derived from the neural crest persist in the leaflets of the atrioventricular valves, but their role in subsequent development remains unknown.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 020697417

Download citation: RISBibTeXText

PMID: 18031480

DOI: 10.1111/j.1469-7580.2007.00833.x


Related references

Cells migrating from the neural crest contribute to the innervation of. 2008

A subpopulation of apoptosis-prone cardiac neural crest cells targets to the venous pole: multiple functions in heart development?. Developmental Biology 207(2): 271-286, 1999

Neural crest cells contribute to heart formation and cardiomyogenesis in zebrafish. Circulation 106(19 Suppl.): II-202-II-203, 2002

Cardiac neural crest cells may contribute to the conduction system in the chick heart. Circulation 80(4 Suppl. 2): II165, 1989

Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart. Developmental Biology 404(2): 103-112, 2015

Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. Journal of Cell Biology 170(7): 1135-1146, 2005

Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent. Cardiovascular Research 109(3): 350-357, 2016

Neural crest cells can chondrify before migrating from neural tubes. Journal of Dental Research 58(SPECIAL ISSUE A): 112, 1979

Early migrating neural crest cells can form ventral neural tube derivatives when challenged by transplantation. Developmental Biology 203(2): 295-304, 1998

Interactions of migrating neural crest cells with fibronectin. Progress in Clinical and Biological Research 226: 127-139, 1986

The neural crest: migrating cells in embryonic development. Folia Morphologica 24(2): 155-172, 1976

Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. Developmental Biology 281(1): 66-77, 2005

Piscine neural crest development: neural crest formation and behavior of neural crest cells in Xiphophorus and Oryzias. GSF-Bericht. 1992( ); 7: 149-160, 1993

The action of concanavalin A on migrating and differentiating neural crest cells. Experimental Cell Research 86(2): 365-373, 1974