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Chimiotherapie de masse par la diethylcarbamazine en doses espacees: effets obtenus a Tahiti sur la microfilaremie a Wuchereria bancrofti var. pacifica



Chimiotherapie de masse par la diethylcarbamazine en doses espacees: effets obtenus a Tahiti sur la microfilaremie a Wuchereria bancrofti var. pacifica



Bulletin of the World Health Organization 585: 779-783



Mass campaigns against lymphatic filariasis employing diethylcarbamazine (DEC) are usually limited in time by the magnitude and cost of the programs advocated. The results given by a chemotherapy program using DEC administered by the spaced dose method (1 dose of DEC/yr) are discussed. This program, which was applied for 4 yr to a Polynesian population numbering 50,000, made it possible to maintain prolonged and continuous pressure on the microfilarial population. The program resulted in reductions in the proportion of carriers from 4.4% to 1.9% and in reducing the average level of microfilaremia in carriers from 21.2 to 11.7 mf/20 mm3 of blood and in the total population studied from 0.9-0.2 mf/20 mm3. Because of practical difficulties in application, the population received, on the average, only 2.76 doses of DEC/person spread over 4 yr. The method used is applicable and effective in the field. Its main advantages are simplicity and low cost, making it suitable for long-term use by basic health services. The effects observed give the hope of a gradual advance towards eradication.

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Accession: 020718311

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