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Effect of fungicide imazalil on hepatic microsomal cytochrome P-450 and cytochrome P-450 dependent activities in the bobwhite quail (Colinus virginianus)



Effect of fungicide imazalil on hepatic microsomal cytochrome P-450 and cytochrome P-450 dependent activities in the bobwhite quail (Colinus virginianus)



Pesticide Science 291: 47-56



Bobwhite quails were treated with imazalil for 8 weeks. The fungicide was given admixed in the food at 0, 100, 300,500 and 1000 mg kg-1. Even at the highest dose tested, imazalil did not affect the liver weight or the hepatic microsomal protein content. In treated quails, no significant induction of cytochrome P-450 or NADPH-cytochrome c-reductase activity was observed. Furthermore, imazalil did not induce or inhibit 7-ethoxyresorufin or 7-ethoxycoumarin O-deethylase in quail microsomes. Only a slight but significant increase by 35% and 49% in aniline hydroxylase activity was measured for the 500- and 1000-mg kg-1 dose levels, respectively. After a drug-free period of one wek, aniline hydroxylase activity returned to control values, indicating that the effect was fully reversible. It is concluded that imazalil does not induce or inhibit drug-metabolizing enzymes in the quail, even at doses which exceed by far the maximum levels currently used to dress seed under field conditions (100 mg kg-1).

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