+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats

Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats

Behavioural Brain Research 187(2): 228-238

Using a rat model of adolescent social stress (SS, daily 1 h isolation and change of cage partner, 30-45 days of age), we have reported sex-specific effects on neuroendocrine function over the course of SS, and enduring effects of SS in females, and not males, on drug-related behaviour. Here, we investigated both the immediate and enduring impact of SS in adolescence on anxiety-like behaviour in the elevated plus maze (EPM) and determined the temporal pattern of corticosterone release after confinement to the open arm of the EPM. When tested as adolescents, SS decreased anxiety-like behaviour in females and had no effect in males. When tested as adults several weeks after the chronic stress, overall, SS tended to increase anxiety-like behaviour in both sexes. However, estrous cycle moderated the effect in females, in that reduced anxiety-like behaviour was observed for SS females in the estrous group. Confinement to the open arm of the EPM increased plasma corticosterone concentrations, which declined markedly upon return to home cage for all except adolescent control males for which corticosterone concentrations at 45 and 90 min were elevated compared other groups. Among controls, anxiety-like behaviour decreased in females and increased in males with age, and confinement to the open arm of the EPM led to a greater increase in corticosterone concentrations in adult males compared to adolescent males. In sum, modest effects of adolescent social stress were observable several weeks after the stress exposure, indicating that sex-specific developmental trajectories and vulnerability to anxiety may be shaped by experiences in adolescence.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 020933678

Download citation: RISBibTeXText

PMID: 17945360

DOI: 10.1016/j.bbr.2007.09.005

Related references

Male Wistar rats are more susceptible to lasting social anxiety than Wild-type Groningen rats following social defeat stress during adolescence. Behavioural Processes 88(2): 76-80, 2011

Effects of troxerutin on anxiety- and depressive-like behaviors induced by chronic mild stress in adult male rats. Iranian Journal of Basic Medical Sciences 21(8): 781-786, 2018

Effects of chronic mild stress on parameters of bone assessment in adult male and female rats. Pesquisa Veterinária Brasileira 36(Suppl 1): 106-112, 2016

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male Long-Evans rats. Developmental Psychobiology 55(8): 849-859, 2013

Effects of interaction of an early experience of reward through maternal contact or its denial with social stress during adolescence on the serotonergic system and the stress responsiveness of adult female rats. Neuroscience 209: 84-96, 2012

Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. Physiology and Behavior 129: 287-296, 2014

Adolescence and the ontogeny of the hormonal stress response in male and female rats and mice. Neuroscience and Biobehavioral Reviews 70: 206-216, 2016

Exposure to Chronic Mild Stress Differentially Alters Corticotropin-Releasing Hormone and Arginine Vasopressin mRNA Expression in the Stress-Responsive Neurocircuitry of Male and Female Rats Prenatally Exposed to Alcohol. Alcoholism Clinical and Experimental Research 39(12): 2414-2421, 2015

Effects of prepubertal stress on subsequent ACTH response to novel stress and CRH in male vs female rats. Stress Medicine 12(3): 204, 1996

Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence. Psychoneuroendocrinology 32(5): 417-429, 2007

Prenatal alcohol exposure and chronic mild stress differentially alter depressive- and anxiety-like behaviors in male and female offspring. Alcoholism Clinical and Experimental Research 34(4): 633-645, 2010

Sex differences in neurotransmission parameters in response to repeated mild restraint stress exposures in intact male, female and ovariectomised female rats. Journal of Neuroendocrinology 19(7): 511-520, 2007

Sympathetic nervous system response to mild stress in male and female rats. FASEB Journal 11(3): A251, 1997

The effects of chronic exposure to varying doses of cocaine on the behavioral stress response in female and male rats. Society for Neuroscience Abstracts 26(1-2): Abstract No. 482-11, 2000

Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior. Neuro Endocrinology Letters 37(Suppl1): 103-110, 2016