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Effects of low protein diet supplemented with alpha -ketoacid on nutritional status and renal interstitial fibrosis in adenine-induced chronic renal failure rats



Effects of low protein diet supplemented with alpha -ketoacid on nutritional status and renal interstitial fibrosis in adenine-induced chronic renal failure rats



Acta Nutrimenta Sinica 30(1): 61-65



In this study, 46 male Wistar rats were divided into two groups: normal control rats (n=10) and chronic renal failure (CRF) rats (n=36, treated with 150 mg/kg body weight per day) adenine intragastrically. After 6 weeks, the CRF rats were divided into three groups, i.e., normal protein diet (NPD, 20% casein diet, n=12), low protein diet (LPD, 6% casein diet, n=12), and LPD+ alpha -ketoacids (5% casein +1% alpha -KA, n=12). All rats were sacrificed at 10 and 14 weeks.

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