+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosis



Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosis



Annals of the Rheumatic Diseases 67(1): 31-36



There is increasing concern about heart and pulmonary vascular involvement in systemic sclerosis (SSc). One of the most severe complications of SSc is pulmonary arterial hypertension (PAH). There has been an increased awareness of left ventricular (LV) diastolic abnormalities in SSc patients. However, previous studies have generally been conducted in small populations. The aims of this study were to prospectively screen for PAH and to describe echocardiographic parameters in a large group of SSc patients. This prospective study was conducted in 21 centres for SSc in France. Patients without severe pulmonary function abnormalities, severe cardiac disease and known PAH underwent Doppler echocardiography performed by a reference cardiologist. Of the 570 patients evaluated, PAH was suspected in 33 patients and was confirmed in 18 by right heart catheterisation. LV systolic dysfunction was rare (1.4%). LV hypertrophy was found in 22.6%, with LV diastolic dysfunction in 17.7%. These LV abnormalities were influenced by age, gender and blood pressure. We identified a small group of 21 patients with a restrictive mitral flow pattern in the absence of any other cardiopulmonary diseases, suggesting a specific cardiac involvement in SSc. Left and right heart diseases, including PAH, LV hypertrophy and diastolic dysfunction, are common in SSc. However, a small subset of patients without any cardiac or pulmonary diseases have a restrictive mitral flow pattern that could be due to primary cardiac involvement of SSc. The prognostic implications of the LV abnormalities will be evaluated in the 3-year follow-up of this cohort.

(PDF emailed within 0-6 h: $19.90)

Accession: 020996978

Download citation: RISBibTeXText

PMID: 17267515

DOI: 10.1136/ard.2006.057760


Related references

Evaluation of cardiac abnormalities in patients with systemic sclerosis by echocardiography and Doppler. American Journal of Noninvasive Cardiology 7(6): 346-352, 1993

Evaluation of cardiac structures and function in systemic sclerosis by Doppler echocardiography. Cardiology 79(3): 165-171, 1991

SAT0206Role of Tissue Doppler Echocardiography in Detecting Preclinical Cardiac Involvement in Systemic Sclerosis Patients. Annals of the Rheumatic Diseases 72(Suppl 3): A650.2-A650, 2013

Evaluation of cardiac functional abnormalities in systemic sclerosis by dobutamine stress echocardiography: a myocardial echostress scleroderma pattern. Annals of the Rheumatic Diseases 65(12): 1669-1670, 2006

Evaluation of the effect of nifedipine upon myocardial perfusion and contractility using cardiac magnetic resonance imaging and tissue Doppler echocardiography in systemic sclerosis. Annals of the Rheumatic Diseases 64(9): 1268-1273, 2005

Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: A controlled study of 100 consecutive patients. Arthritis and Rheumatism 58(6): 1803-1809, 2008

Pulmonary hypertension in systemic sclerosis: prevalence, incidence and predictive factors in a large multicentric Italian cohort. Clinical and Experimental Rheumatology 31(2 Suppl 76): 31-36, 2013

Evaluation of left and right ventricle by two-dimensional speckle tracking echocardiography in systemic sclerosis patients without overt cardiac disease. Clinical Rheumatology 2019, 2019

Screening for PAH in patients with systemic sclerosis: focus on Doppler echocardiography. Rheumatology 47 Suppl 5: V33-V35, 2008

Evaluation of Left Ventricular Diastolic Function by Echocardiography with Tissue Doppler in Systemic Sclerosis. Arquivos Brasileiros de Cardiologia 109(5): 410-415, 2017

Early detection of cardiac involvement in systemic sclerosis assessed by tissue-Doppler echocardiography: relationship with neurohormonal activation and endothelial dysfunction. Journal of Rheumatology 37(5): 993-999, 2010

Alzheimer's Disease in Systemic Sclerosis Patients: A Nationwide Population-Based Cohort Study. Journal of Alzheimer's Disease 65(1): 117-124, 2018

Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. Results of a large, multicentric, nationwide study. Journal of Autoimmunity 86: 1-8, 2017

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary circulation in patients with systemic sclerosis. Advances in Medical Sciences 64(2): 309-314, 2019

Intravenous immunoglobulins in systemic sclerosis: Data from a French nationwide cohort of 46 patients and review of the literature. Autoimmunity Reviews 16(4): 377-384, 2017