+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies



Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies



American Journal of Epidemiology 166(10): 1116-1125



Animal studies show favorable effects of n-3 fatty acids on inflammation and cancer, but results from epidemiologic studies appear to be inconsistent. The authors conducted meta-analyses of prospective cohort studies that evaluated the association between fish consumption or n-3 fatty acids and colorectal cancer incidence or mortality. Random-effects models were used, and heterogeneity between study results was explored through stratified analyses. The pooled relative risks for the highest compared with the lowest fish consumption category were 0.88 (95% confidence interval: 0.78, 1.00) for colorectal cancer incidence (14 studies) and 1.02 (95% confidence interval: 0.90, 1.16) for colorectal cancer mortality (four studies). The pooled relative risks for colorectal cancer incidence were 0.96 (95% confidence interval: 0.92, 1.00) for each extra occurrence of fish consumption per week (seven studies) and 0.97 (95% confidence interval: 0.92, 1.03) for each extra 100 g of fish consumed per week (four studies). Stratified analysis showed that the pooled relative risk for colorectal cancer incidence was more pronounced for women and in studies with a large exposure contrast. In cohort studies, fish consumption was shown to slightly reduce colorectal cancer risk. Existing evidence that n-3 fatty acids inhibit colorectal carcinogenesis is in line with these results, but few data are available addressing this association.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 021045641

Download citation: RISBibTeXText

PMID: 17823383

DOI: 10.1093/aje/kwm197


Related references

Fish, long chain omega-3 polyunsaturated fatty acids consumption, and risk of all-cause mortality: a systematic review and dose-response meta-analysis from 23 independent prospective cohort studies. Asia Pacific Journal of Clinical Nutrition 26(5): 939-956, 2017

Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ 346: F3706-F3706, 2013

Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. International Journal of Cancer 138(8): 1894-1904, 2016

Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies. Oncotarget 8(12): 18699-18711, 2017

Coffee consumption and colorectal cancer risk: a dose-response meta-analysis on prospective cohort studies. International Journal of Food Sciences and Nutrition 70(8): 986, 2019

Coffee consumption and risk of colorectal cancer: a systematic review and meta-analysis of prospective cohort studies. International Journal of Cancer 124(7): 1662-1668, 2009

N-3 polyunsaturated fatty acids intake and risk of colorectal cancer: meta-analysis of prospective studies. Cancer Causes and Control 26(1): 133-141, 2015

Fish consumption, dietary long-chain n-3 fatty acids, and risk of type 2 diabetes: systematic review and meta-analysis of prospective studies. Diabetes Care 35(4): 918-929, 2012

Dietary n-3 polyunsaturated fatty acids, fish consumption, and endometrial cancer risk: a meta-analysis of epidemiological studies. Oncotarget 8(53): 91684-91693, 2017

Effect of individual omega-3 fatty acids on the risk of prostate cancer: a systematic review and dose-response meta-analysis of prospective cohort studies. Journal of Epidemiology 25(4): 261-274, 2015

Fish Consumption and Stroke Risk: A Meta-Analysis of Prospective Cohort Studies. Journal of Stroke and Cerebrovascular Diseases 28(3): 604-611, 2019

Fish consumption and incidence of heart failure: a meta-analysis of prospective cohort studies. Chinese Medical Journal 126(5): 942-948, 2013

Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: a meta-analytical approach. Cancer Epidemiology, Biomarkers & Prevention 10(5): 439-446, 2001

Fish consumption and risk of stroke and its subtypes: accumulative evidence from a meta-analysis of prospective cohort studies. European Journal of Clinical Nutrition 66(11): 1199-1207, 2012

Association between omega-3 fatty acids consumption and the risk of type 2 diabetes: A meta-analysis of cohort studies. Journal of Diabetes Investigation 8(4): 480-488, 2017