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In vitro replication of Nosema algerae (Microsporidia), a parasite of anopheline mosquitoes, in human cells above 36 C

In vitro replication of Nosema algerae (Microsporidia), a parasite of anopheline mosquitoes, in human cells above 36 C

Journal of Eukaryotic Microbiology. September-October; 465: 464-468

Microsporidia form a large and ubiquitous group of obligately intracellular parasitic eukaryotes, increasingly recognized as pathogens in humans. Transmission of invertebrate microsporidia to mammals has been considered impossible because temperature seemed to be a limiting factor for development. Nosema algerae, a microsporidian of anopheline mosquitoes, was cultured in human muscle fibroblasts at temperatures of 31degree C and 38degree C. This is the first record of an invertebrate microsporidian developing in human cells at a temperature above 36degree C. The ultrastructure of N. algerae growing in human muscle fibroblasts is similar to that of Brachiola vesicularum, a microsporidian species previously described in the muscle of an AIDS patient.

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Accession: 021180306

Download citation: RISBibTeXText

PMID: 10519213

DOI: 10.1111/j.1550-7408.1999.tb06062.x

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In vitro replication of Nosema algerae , a parasite of anopheline mosquitoes, in human cells above 36degree C. Journal of Eukaryotic Microbiology 46(5): 464-468, 1999

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