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Oxidative stress and chronic kidney disease



Oxidative stress and chronic kidney disease



Veterinary Clinics of North America. Small Animal Practice 38(1): 157-66, Vi



Slowing the rate of progression of chronic kidney disease (CKD) is a critical part of the management of affected dogs and cats. Renal oxidant stress is a previously unrecognized factor in the progression of canine CKD and is likely to be similarly important in feline CKD. Renin-angiotensin antagonism, calcium channel antagonism, n-3 polyunsaturated fatty acid, and antihypertensive and antiproteinuric therapy are commonly recommended for dogs and cats with CKD. These therapies would be expected to reduce renal oxidant stress by decreasing reactive oxygen species generation. Newer data indicate that dietary supplementation with specific antioxidants is an important consideration for limiting renal oxidant stress and progression of CKD.

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Accession: 021513558

Download citation: RISBibTeXText

PMID: 18249247

DOI: 10.1016/j.cvsm.2007.11.001


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