Persistent calcium inward current in internally perfused snail neuron

Oyama, Y.; Akaike, N.; Nishi, K.

Cellular and Molecular Neurobiology 6(1): 71-85

1986


ISSN/ISBN: 0272-4340
PMID: 2424600
DOI: 10.1007/bf00742977
Accession: 021540119

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
1. The inactivation process of the calcium current (ICa) was investigated in a molluscan neuron which was perfused intracellularly and voltage-clamped using a suction pipette technique. 2. The decay phase of the ICa contained a very slowly inactivated component (persistent inward current; PIC). The decay time constant of this component was over 10 sec. 3. An increase in the amplitude of the ICa or the intracellular Ca2+ concentration caused a decrease in the decay time constant of the PIC. 4. Replacing Ba2+ with extracellular Ca2+ increased the decay time constant of the PIC. The differences in the amplitude and the decay kinetics between the ICa and the IBa resulted from changes in the amplitude and the decay time constant of the PIC. 5. These observations support the conclusion that the inactivation of the PIC is calcium dependent Chad, J., Eckert, R., and Ewald, D. (1984). J. Physiol. (Lond.) 347:279-300 .

Persistent calcium inward current in internally perfused snail neuron