+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Possible role of C-reactive protein in detoxification of mercury

Possible role of C-reactive protein in detoxification of mercury

Indian Journal of Experimental Biology, 287: 638-641

In mercury-treated rats, C-reactive protein (CRP) has been found to be synthesized in the liver which, in turn, sequesters mercury resulting in the denaturation of the protein into subunits. The subunits retain the mercury and are released into the serum from where it gets excreted. Native CRP and CRP-subunits have been found to have different antigenicity. Thus one of the physiological roles of CRp seems to be detoxication of heavy metals.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 021576347

Download citation: RISBibTeXText

PMID: 2272649

Related references

Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system. Biochemistry 36(23): 6885-6895, 1997

Atmospheric mercury in Changbai Mountain area, northeastern China II. The distribution of reactive gaseous mercury and particulate mercury and mercury deposition fluxes. Environmental Research 109(6): 721-727, 2009

Diurnal variations of total mercury THg, reactive mercury RHg, and dissolved gaseous mercury and water/air mercury flux in warm and cold season from fresh waters of Southwestern China. 2013

Diurnal variations of total mercury, reactive mercury, and dissolved gaseous mercury concentrations and water/air mercury flux in warm and cold seasons from freshwaters of southwestern China. Environmental Toxicology and Chemistry 32(10): 2256-2265, 2013

Detoxification of mercury by selenium by binding of equimolar Hg-Se complex to a specific plasma protein. Toxicology and Applied Pharmacology 143(2): 274-280, 1997

Multidimensional NMR studies of a transport protein, MERP, from the bacterial mercury detoxification system. Journal of Cellular Biochemistry Supplement 0(21B): 37, 1995

Role of glutathione S-transferases A1-1, M1-1, and P1-1 in the detoxification of 2-phenylpropenal, a reactive felbamate metabolite. Chemical Research in Toxicology 14(5): 511-516, 2001

The role of metallothioneins, selenium and transfer to offspring in mercury detoxification in Franciscana dolphins (Pontoporia blainvillei). Marine Pollution Bulletin 109(1): 650-654, 2017

Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling. Toxicology and Applied Pharmacology 196(1): 47-57, 2004

Role of platelet-released growth factors in detoxification of reactive oxygen species in osteoblasts. Bone 65: 9-17, 2015

Measurement of Particulate Bound Mercury, Gaseous Elemental Mercury, and Reactive Gaseous Mercury Concentrations by Using an Ambient Air Mercury Collection System. Environmental Forensics 16(4): 305-309, 2015

Cleaving mercury-alkyl bonds: a functional model for mercury detoxification by MerB. Science 317(5835): 225-227, 2007

NMR structure determination of a membrane protein with two transmembrane helices in micelles: MerF of the bacterial mercury detoxification system. Biochemistry 44(13): 5196-5206, 2005

Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes. Frontiers in Immunology 9: 1351, 2018

Deposition of C-reactive protein in the arterial intima Role of C-reactive protein receptor-dependent recruitment of monocytes in atherogenesis. Circulation 102(18 Supplement): II 330, October 31, 2000