+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction



Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction



Current Genomics 8(7): 423-428



Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling pathways involved in the control of lifespans in lower organisms to mammals. Caloric restriction (CR) reduces plasma concentration of insulin, growth hormone (GH), and IGF-I. CR retards various age-dependent disorders such as nuerodegenerative diseases and extends lifespan in laboratory rodents.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 021703209

Download citation: RISBibTeXText

PMID: 19412415

DOI: 10.2174/138920207783591726


Related references

Role of the growth hormone-insulin-like growth factor-1-insulin system signaling in aging and longevity: evolutional aspect. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 94(9): 1092-1109, 2008

Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis. Experimental Gerontology 43(9): 827-832, 2008

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology 146(2): 851-860, 2005

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. Plos one 4(2): E4567, 2009

Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging. Stem Cell Reviews and Reports 13(4): 443-453, 2017

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 cotreatment versus insulin-like growth factor-I alone in two brothers with growth hormone insensitivity syndrome: effects on insulin sensitivity, body composition and linear growth. Hormone Research in Paediatrics 76(5): 355-366, 2011

Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report. Journal of Medical Case Reports 4: 305, 2010

Role of insulin/insulin-like growth factor 1 signaling pathway in longevity. World Journal of Gastroenterology 11(13): 1891-1895, 2005

Circulating insulin-like growth factor I, insulin-like growth factor binding proteins, growth hormone, and resumption of estrus in postpartum cows subjected to dietary energy restriction. Journal of Animal Science 75(7): 1909-1917, 1997

Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. Faseb Journal 17(9): 1108-1109, 2003

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction. Journal of Perinatal Medicine 39(6): 701-707, 2011

Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction. Journals of Gerontology. Series A Biological Sciences and Medical Sciences 63(8): 788-797, 2008

Plasma growth hormone, insulin-like growth factor, insulin, and thyroid hormone association with body protein and fat accretion in steers undergoing compensatory gain after dietary energy restriction. Journal of Animal Science 71(12): 3327-3338, 1993

The aging brain: is function dependent on growth hormone/insulin-like growth factor-1 signaling?. Age 28(2): 173-180, 2006

Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle. Human Reproduction 12(10): 2123-2128, 1997