+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293(4): R1671-R1683
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Several studies have shown the occurrence of an independent association between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease, including arterial hypertension, ischemic heart disease, and stroke. The pathogenesis of the cardiovascular complications of OSAS is still poorly understood, however. Several mechanisms are likely to be involved, including sympathetic overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormality in the process of coagulation, and metabolic dysregulation. The latter may involve insulin resistance and disorders of lipid metabolism. The aim of this review, which reports the data presented at a workshop jointly endorsed by the European Society of Hypertension and by the European Union COST action on OSAS (COST B26), is to critically summarize the evidence available to support an independent association between OSAS and cardiovascular disease.

(PDF same-day service: $19.90)

Accession: 021758519

PMID: 17652356

DOI: 10.1152/ajpregu.00400.2007

Related references

Pathophysiology of cardiovascular risk in sleep apnea syndrome (SAS). Revue Neurologique 158(8-9): 785-797, 2002

Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk. Sleep Medicine Clinics 11(3): 273-286, 2016

Headache in sleep apnea syndrome: epidemiology and pathophysiology. Cephalalgia 34(10): 752-755, 2015

Sleep apnea and heart failure--pathophysiology and epidemiology. Praxis und Klinik der Pneumologie 41(10): 394-396, 1987

Epidemiology, pathophysiology, and clinical features of obstructive sleep apnea. Oral and Maxillofacial Surgery Clinics of North America 21(4): 369-375, 2010

Epidemiology of sleep?related complaints associated with obstructive sleep apnea, insomnia and non?restorative sleep in an at?risk population in Granada, Spain. Sleep and Biological Rhythms 10(3), 2012

Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae. Korean Journal of Pediatrics 53(10): 863-871, 2010

Sleep Apnea Cardiovascular Clinical Trials-Current Status and Steps Forward: The International Collaboration of Sleep Apnea Cardiovascular Trialists. Sleep 36(7): 975-980, 2013

Ask the doctors. I have always had a snoring problem and recently underwent a sleep test at the insistence of my wife. I was diagnosed as having sleep apnea. We have read about the connection between sleep apnea and heart disease, and now we are both concerned. Will treating my sleep apnea reduce my heart risk?. Harvard Heart Letter 23(5): 2-2, 2013

Obstructive Sleep Apnea Syndrome: Links Betwen Pathophysiology and Cardiovascular Complications. Clinical and Investigative Medicine. Medecine Clinique et Experimentale 38(6): E362-E370, 2016