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T lymphocyte recognition of acetylcholine receptor: localization of the full T cell recognition profile on the extracellular part of the chain of Torpedo californica acetylcholine receptor



T lymphocyte recognition of acetylcholine receptor: localization of the full T cell recognition profile on the extracellular part of the chain of Torpedo californica acetylcholine receptor



European Journal of Immunology, 1712: 1697-1702



A series of eighteen consecutive overlapping synthetic peptides, of uniform size and overlaps, which encompass the entire extracellular part (residues 1-210) of the Torpeda californica acetylcholine receptor .alpha. chain were examined in vitro for their ability to stimulate lymph node cells from acetylcholine receptor-primed C57BL/6 (H-2b), C3H/He (H-2k), SWR (H-2q) and SJL (H-2s) mice. The recognition sites (T sites) by acetylcholine receptor-primed lymph node cells from these mouse strains resided within six regions on the extracellular part of the .alpha. chain. Three of the regions recognized by T cells coincided with regions recognized by antibodies (i.e. B cells) and one of these three regions also coincided with an .alpha.-neurotoxin-binding region. It is noteworthy that, in addition to sites recognized by both T and B cells, the protein has at least two sites which are recognized exclusively by T cells and to which no detectable antibody responses are directed.

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Accession: 021848979

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DOI: 10.1002/eji.1830171204


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